amiodarone [Ligand Id: 2566] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL633 (L-3428, Amiodarone, Cordarone, SKF-33134A, Pacerone)
  • 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human [ChEMBL: CHEMBL4931] [UniProtKB: Q15125]
  • This target only has 1 pki data point
1 CHEMBL633_lig_chart_1 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Human
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  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
  • This target only has 1 pki data point
2 CHEMBL633_lig_chart_2 Adenosine A3 receptor Human
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
  • This target only has 1 pki data point
3 CHEMBL633_lig_chart_3 Alpha-2a adrenergic receptor Human
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
  • This target only has 1 pki data point
4 CHEMBL633_lig_chart_4 Alpha-2b adrenergic receptor Human
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  • Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
  • This target only has 1 pki data point
5 CHEMBL633_lig_chart_5 Androgen Receptor Rat
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  • Anthrax lethal factor in Bacillus anthracis [ChEMBL: CHEMBL4372] [UniProtKB: P15917]
  • This target only has 0 pki data point
6 CHEMBL633_lig_chart_6 Anthrax lethal factor Bacillus anthracis
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  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • This target only has 1 pki data point
7 CHEMBL633_lig_chart_7 Beta-1 adrenergic receptor Human
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  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
  • This target only has 1 pki data point
8 CHEMBL633_lig_chart_8 Beta-3 adrenergic receptor Human
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  • B2 receptor/Bradykinin B2 receptor in Human [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
  • This target only has 1 pki data point
9 CHEMBL633_lig_chart_9 Bradykinin B2 receptor Human
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  • C-8 sterol isomerase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL3224] [UniProtKB: P32352]
  • This target only has 1 pki data point
10 CHEMBL633_lig_chart_10 C-8 sterol isomerase Saccharomyces cerevisiae S288c
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  • Carnitine O-palmitoyltransferase 1, muscle isoform in Human [ChEMBL: CHEMBL2216739] [UniProtKB: Q92523]
  • This target only has 0 pki data point
11 CHEMBL633_lig_chart_11 Carnitine O-palmitoyltransferase 1, muscle isoform Human
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  • Carnitine palmitoyltransferase 2 in Human [ChEMBL: CHEMBL3238] [UniProtKB: P23786]
  • This target only has 0 pki data point
12 CHEMBL633_lig_chart_12 Carnitine palmitoyltransferase 2 Human
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  • CCR2/C-C chemokine receptor type 2 in Human [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597]
  • This target only has 1 pki data point
13 CHEMBL633_lig_chart_13 C-C chemokine receptor type 2 Human
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  • CCR4/C-C chemokine receptor type 4 in Human [ChEMBL: CHEMBL2414] [GtoPdb: 61] [UniProtKB: P51679]
  • This target only has 1 pki data point
14 CHEMBL633_lig_chart_14 C-C chemokine receptor type 4 Human
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  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
  • This target only has 1 pki data point
15 CHEMBL633_lig_chart_15 Delta opioid receptor Human
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  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
  • This target only has 1 pki data point
16 CHEMBL633_lig_chart_16 Dopamine D1 receptor Human
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • This target only has 1 pki data point
17 CHEMBL633_lig_chart_17 Dopamine D2 receptor Human
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • This target only has 1 pki data point
18 CHEMBL633_lig_chart_18 Dopamine D3 receptor Human
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
  • This target only has 1 pki data point
19 CHEMBL633_lig_chart_19 Dopamine D4 receptor Human
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  • DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
  • This target only has 1 pki data point
20 CHEMBL633_lig_chart_20 Dopamine transporter Human
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  • ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
  • This target only has 1 pki data point
21 CHEMBL633_lig_chart_21 Endothelin receptor ET-A Human
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  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 0 pki data point
22 CHEMBL633_lig_chart_22 HERG Human
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  • H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
  • This target only has 1 pki data point
23 CHEMBL633_lig_chart_23 Histamine H2 receptor Human
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  • κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
  • This target only has 1 pki data point
24 CHEMBL633_lig_chart_24 Kappa opioid receptor Human
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  • lysine demethylase 5A/Lysine-specific demethylase 5A in Human [ChEMBL: CHEMBL2424504] [GtoPdb: 2680] [UniProtKB: P29375]
  • This target only has 0 pki data point
25 CHEMBL633_lig_chart_25 Lysine-specific demethylase 5A Human
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  • lysine demethylase 7A/Lysine-specific demethylase 7 in Human [ChEMBL: CHEMBL2163177] [GtoPdb: 2686] [UniProtKB: Q6ZMT4]
  • This target only has 0 pki data point
26 CHEMBL633_lig_chart_26 Lysine-specific demethylase 7 Human
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  • PHD finger protein 2/Lysine-specific demethylase PHF2 in Human [ChEMBL: CHEMBL4295672] [GtoPdb: 2697] [UniProtKB: O75151]
  • This target only has 0 pki data point
27 CHEMBL633_lig_chart_27 Lysine-specific demethylase PHF2 Human
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  • MC3 receptor/Melanocortin receptor 3 in Human [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968]
  • This target only has 1 pki data point
28 CHEMBL633_lig_chart_28 Melanocortin receptor 3 Human
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  • MC4 receptor/Melanocortin receptor 4 in Human [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245]
  • This target only has 1 pki data point
29 CHEMBL633_lig_chart_29 Melanocortin receptor 4 Human
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  • MC5 receptor/Melanocortin receptor 5 in Human [ChEMBL: CHEMBL4608] [GtoPdb: 286] [UniProtKB: P33032]
  • This target only has 1 pki data point
30 CHEMBL633_lig_chart_30 Melanocortin receptor 5 Human
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  • μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
  • This target only has 1 pki data point
31 CHEMBL633_lig_chart_31 Mu opioid receptor Human
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • This target only has 1 pki data point
32 CHEMBL633_lig_chart_32 Muscarinic acetylcholine receptor M1 Human
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • This target only has 1 pki data point
33 CHEMBL633_lig_chart_33 Muscarinic acetylcholine receptor M2 Human
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
  • This target only has 1 pki data point
34 CHEMBL633_lig_chart_34 Muscarinic acetylcholine receptor M3 Human
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  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
  • This target only has 1 pki data point
35 CHEMBL633_lig_chart_35 Muscarinic acetylcholine receptor M4 Human
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  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
  • This target only has 1 pki data point
36 CHEMBL633_lig_chart_36 Muscarinic acetylcholine receptor M5 Human
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  • NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
  • This target only has 1 pki data point
37 CHEMBL633_lig_chart_37 Neurokinin 2 receptor Human
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  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
  • This target only has 1 pki data point
38 CHEMBL633_lig_chart_38 Norepinephrine transporter Human
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39 CHEMBL633_lig_chart_39 P-glycoprotein 1 HumanMouse
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  • ABCB1/P-glycoprotein 3 in Mouse [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447]
  • This target only has 1 pki data point
40 CHEMBL633_lig_chart_40 P-glycoprotein 3 Mouse
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
41 CHEMBL633_lig_chart_41 Plasmodium falciparum Plasmodium falciparum
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  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
  • This target only has 0 pki data point
42 CHEMBL633_lig_chart_42 Receptor protein-tyrosine kinase erbB-2 Human
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
  • This target only has 1 pki data point
43 CHEMBL633_lig_chart_43 Serotonin 1b (5-HT1b) receptor Rat
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • This target only has 1 pki data point
44 CHEMBL633_lig_chart_44 Serotonin 2a (5-HT2a) receptor Human
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
  • This target only has 1 pki data point
45 CHEMBL633_lig_chart_45 Serotonin 2b (5-HT2b) receptor Human
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • This target only has 1 pki data point
46 CHEMBL633_lig_chart_46 Serotonin 2c (5-HT2c) receptor Human
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
  • This target only has 1 pki data point
47 CHEMBL633_lig_chart_47 Serotonin 6 (5-HT6) receptor Human
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
  • This target only has 1 pki data point
48 CHEMBL633_lig_chart_48 Serotonin transporter Human
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
49 CHEMBL633_lig_chart_49 Sigma opioid receptor Human
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  • Solute carrier organic anion transporter family member 1A4 in Rat [ChEMBL: CHEMBL1781860] [UniProtKB: O35913]
  • This target only has 1 pki data point
50 CHEMBL633_lig_chart_50 Solute carrier organic anion transporter family member 1A4 Rat
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  • squalene monooxygenase/Squalene monooxygenase in Human [ChEMBL: CHEMBL3592] [GtoPdb: 2433] [UniProtKB: Q14534]
  • This target only has 0 pki data point
51 CHEMBL633_lig_chart_51 Squalene monooxygenase Human
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  • squalene synthase /Squalene synthetase in Human [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268]
  • This target only has 0 pki data point
52 CHEMBL633_lig_chart_52 Squalene synthetase Human
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  • Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827]
  • This target only has 0 pki data point
53 CHEMBL633_lig_chart_53 Thyroid hormone receptor alpha Human
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  • Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828]
  • This target only has 0 pki data point
54 CHEMBL633_lig_chart_54 Thyroid hormone receptor beta-1 Human
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  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
  • This target only has 0 pki data point
55 CHEMBL633_lig_chart_55 Tyrosine-protein kinase FYN Human
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  • Kv1.7 in Human [GtoPdb: 544] [UniProtKB: Q96RP8]
  • This target only has 0 pki data point
56 CHEMBL633_lig_chart_56 Kv1.7 Human
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  • Nav1.5 in Rat [GtoPdb: 582] [UniProtKB: P15389]
  • This target only has 0 pki data point
57 CHEMBL633_lig_chart_57 Nav1.5 Rat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4931] [UniProtKB: Q15125]
ChEMBL Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand B 7.6 pKi 25 nM