Top ▲

squalene monooxygenase

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2433

Nomenclature: squalene monooxygenase

Family: Lanosterol biosynthesis pathway

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 574 8q24.1 SQLE squalene epoxidase 3
Mouse - 572 15 25.16cM Sqle squalene epoxidase
Rat - 573 7q33 Sqle squalene epoxidase
Previous and Unofficial Names Click here for help
SE | squalene epoxidase
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.14.13.132 H+ + NADPH + O2 + squalene = H2O + NADP+ + (S)-2,3-epoxysqualene
Cofactors Click here for help
Cofactor Species Comments Reference
flavin adenine dinucleotide Human 2

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 1b [PMID: 9871762] Small molecule or natural product Hs Inhibition 7.2 pIC50 1
pIC50 7.2 (IC50 6x10-8 M) [1]
Tissue Distribution Click here for help
Liver
Species:  Human
Technique:  PCR
References:  2

References

Show »

1. Gotteland JP, Loubat C, Planty B, Junquéro D, Delhon A, Halazy S. (1998) Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors. Bioorg. Med. Chem. Lett., 8 (11): 1337-42. [PMID:9871762]

2. Laden BP, Tang Y, Porter TD. (2000) Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase. Arch. Biochem. Biophys., 374 (2): 381-8. [PMID:10666321]

3. Nagai M, Sakakibara J, Wakui K, Fukushima Y, Igarashi S, Tsuji S, Arakawa M, Ono T. (1997) Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1. Genomics, 44 (1): 141-3. [PMID:9286711]

Contributors

Show »

How to cite this page