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Lanosterol biosynthesis pathway C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Lanosterol is a precursor for cholesterol, which is synthesized primarily in the liver in a pathway often described as the mevalonate or HMG-CoA reductase pathway. The first two steps (formation of acetoacetyl CoA and the mitochondrial generation of (S)-3-hydroxy-3-methylglutaryl-CoA) are also associated with oxidation of fatty acids.

Enzymes

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acetyl-CoA acetyltransferase 1 C Show summary » More detailed page go icon to follow link

acetyl-CoA acetyltransferase 2 C Show summary » More detailed page go icon to follow link

hydroxymethylglutaryl-CoA synthase 1 C Show summary » More detailed page go icon to follow link

hydroxymethylglutaryl-CoA synthase 2 C Show summary » More detailed page go icon to follow link

hydroxymethylglutaryl-CoA reductase C Show summary » More detailed page go icon to follow link

mevalonate kinase C Show summary » More detailed page go icon to follow link

phosphomevalonate kinase C Show summary » More detailed page go icon to follow link

diphosphomevalonate decarboxylase C Show summary » More detailed page go icon to follow link

isopentenyl-diphosphate Δ-isomerase 1 C Show summary » More detailed page go icon to follow link

isopentenyl-diphosphate Δ-isomerase 2 C Show summary » More detailed page go icon to follow link

geranylgeranyl diphosphate synthase C Show summary » More detailed page go icon to follow link

farnesyl diphosphate synthase C Show summary » More detailed page go icon to follow link

squalene synthase C Show summary » More detailed page go icon to follow link

squalene monooxygenase C Show summary » More detailed page go icon to follow link

lanosterol synthase C Show summary » More detailed page go icon to follow link

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.