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carnitine palmitoyltransferase 2

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Target not currently curated in GtoImmuPdb

Target id: 3252

Nomenclature: carnitine palmitoyltransferase 2

Family: Carnitine palmitoyltransferases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 658 1p32.3 CPT2 carnitine palmitoyltransferase 2
Mouse - 658 4 50.18 cM Cpt2 carnitine palmitoyltransferase 2
Rat - 658 5q34 Cpt2 carnitine palmitoyltransferase 2
Previous and Unofficial Names Click here for help
carnitine O-palmitoyltransferase 2 | Carnitine O-palmitoyltransferase 2, mitochondrial
Database Links Click here for help
Alphafold P23786 (Hs), P52825 (Mm), P18886 (Rn)
BRENDA 3.2.1.21
ChEMBL Target CHEMBL3238 (Hs), CHEMBL4037 (Rn)
Ensembl Gene ENSG00000157184 (Hs), ENSMUSG00000028607 (Mm), ENSRNOG00000012443 (Rn)
Entrez Gene 1376 (Hs), 12896 (Mm), 25413 (Rn)
Human Protein Atlas ENSG00000157184 (Hs)
KEGG Enzyme 3.2.1.21
KEGG Gene hsa:1376 (Hs), mmu:12896 (Mm), rno:25413 (Rn)
OMIM 600650 (Hs)
Pharos P23786 (Hs)
UniProtKB P23786 (Hs), P52825 (Mm), P18886 (Rn)
Wikipedia CPT2 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.2.1.21

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 16 [PMID: 17585909] Small molecule or natural product Ligand has a PDB structure Rn Inhibition 6.7 pIC50 1
⤷ pIC50 6.7 (IC50 2.1x10-7 M) [1]
teglicar Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn Inhibition 6.6 pIC50 2
⤷ pIC50 6.6 (IC50 2.4x10-7 M) [2]

References

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1. Rufer AC, Lomize A, Benz J, Chomienne O, Thoma R, Hennig M. (2007) Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog. FEBS Lett, 581 (17): 3247-52. [PMID:17585909]

2. Rufer AC, Thoma R, Benz J, Stihle M, Gsell B, De Roo E, Banner DW, Mueller F, Chomienne O, Hennig M. (2006) The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment. Structure, 14 (4): 713-23. [PMID:16615913]

How to cite this page

Carnitine palmitoyltransferases: carnitine palmitoyltransferase 2. Last modified on 06/02/2024. Accessed on 29/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3252.