PD98059 [Ligand Id: 5241] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL35482 (PD-98059) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibitory activity against Prostaglandin G/H synthase 1 (COX-1) | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2003) 46: 1478-1483 [PMID:12672248] |
| mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
| ChEMBL | Inhibition of MEK1 phosphorylation by activated human recombinant Raf | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2002) 45: 529-532 [PMID:11784156] |
| ChEMBL | Inhibition of MEK1 (unknown origin) | B | 5.4 | pIC50 | 4000 | nM | IC50 | Medchemcomm (2013) 4: 135-139 |
| ChEMBL | Inhibition of Mitogen activated protein kinase kinase 1 (MKK1) | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2003) 46: 1478-1483 [PMID:12672248] |
| mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507] | ||||||||
| ChEMBL | Inhibition of MEK2 (unknown origin) | B | 4.3 | pIC50 | 50000 | nM | IC50 | Medchemcomm (2013) 4: 135-139 |
| Luciferin 4-monooxygenase in Photinus pyralis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5567] [UniProtKB: P08659] | ||||||||
| ChEMBL | Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2008) 51: 2372-2386 [PMID:18363348] |
| ChEMBL | Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay | B | 4.22 | pIC50 | 60000 | nM | IC50 | J Med Chem (2008) 51: 2372-2386 [PMID:18363348] |
| ChEMBL | Inhibition of Photinus pyralis luciferase by Easy lite assay | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (2008) 51: 2372-2386 [PMID:18363348] |
| ChEMBL | Inhibition of Photinus pyralis luciferase by PK-Light assay | B | 5.19 | pIC50 | 6400 | nM | IC50 | J Med Chem (2008) 51: 2372-2386 [PMID:18363348] |
| ChEMBL | Inhibition of Photinus pyralis luciferase | B | 5.21 | pIC50 | 6200 | nM | IC50 | J Med Chem (2008) 51: 2372-2386 [PMID:18363348] |
| mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 | B | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (2002) 45: 529-532 [PMID:11784156] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
