PD98059 [Ligand Id: 5241] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL35482 (PD-98059)
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  • mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
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  • mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507]
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  • Luciferin 4-monooxygenase in Photinus pyralis [ChEMBL: CHEMBL5567] [UniProtKB: P08659]
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  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibitory activity against Prostaglandin G/H synthase 1 (COX-1) B 6 pIC50 1000 nM IC50 J. Med. Chem. (2003) 46: 1478-1483 [PMID:12672248]
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
ChEMBL Inhibition of MEK1 phosphorylation by activated human recombinant Raf B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2002) 45: 529-532 [PMID:11784156]
ChEMBL Inhibition of MEK1 (unknown origin) B 5.4 pIC50 4000 nM IC50 MedChemComm (2013) 4: 135-139
ChEMBL Inhibition of Mitogen activated protein kinase kinase 1 (MKK1) B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (2003) 46: 1478-1483 [PMID:12672248]
mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507]
ChEMBL Inhibition of MEK2 (unknown origin) B 4.3 pIC50 50000 nM IC50 MedChemComm (2013) 4: 135-139
Luciferin 4-monooxygenase in Photinus pyralis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5567] [UniProtKB: P08659]
ChEMBL Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assay B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay B 4.22 pIC50 60000 nM IC50 J. Med. Chem. (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL Inhibition of Photinus pyralis luciferase by Easy lite assay B 4.96 pIC50 11000 nM IC50 J. Med. Chem. (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL Inhibition of Photinus pyralis luciferase by PK-Light assay B 5.19 pIC50 6400 nM IC50 J. Med. Chem. (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL Inhibition of Photinus pyralis luciferase B 5.21 pIC50 6200 nM IC50 J. Med. Chem. (2008) 51: 2372-2386 [PMID:18363348]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 B 5.55 pIC50 2800 nM IC50 J. Med. Chem. (2002) 45: 529-532 [PMID:11784156]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]