PD98059 [Ligand Id: 5241] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL35482 (PD-98059) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibitory activity against Prostaglandin G/H synthase 1 (COX-1) | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2003) 46: 1478-1483 [PMID:12672248] |
| mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
| ChEMBL | Inhibition of MEK1 phosphorylation by activated human recombinant Raf | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2002) 45: 529-532 [PMID:11784156] |
| ChEMBL | Inhibition of MEK1 (unknown origin) | B | 5.4 | pIC50 | 4000 | nM | IC50 | Medchemcomm (2013) 4: 135-139 |
| ChEMBL | Inhibition of Mitogen activated protein kinase kinase 1 (MKK1) | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2003) 46: 1478-1483 [PMID:12672248] |
| mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507] | ||||||||
| ChEMBL | Inhibition of MEK2 (unknown origin) | B | 4.3 | pIC50 | 50000 | nM | IC50 | Medchemcomm (2013) 4: 135-139 |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate | B | 5.74 | pIC50 | 1837 | nM | IC50 | HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators |
| Luciferin 4-monooxygenase in Photinus pyralis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5567] [UniProtKB: P08659] | ||||||||
| ChEMBL | Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2008) 51: 2372-2386 [PMID:18363348] |
| ChEMBL | Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay | B | 4.22 | pIC50 | 60000 | nM | IC50 | J Med Chem (2008) 51: 2372-2386 [PMID:18363348] |
| ChEMBL | Inhibition of Photinus pyralis luciferase by Easy lite assay | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (2008) 51: 2372-2386 [PMID:18363348] |
| ChEMBL | Inhibition of Photinus pyralis luciferase by PK-Light assay | B | 5.19 | pIC50 | 6400 | nM | IC50 | J Med Chem (2008) 51: 2372-2386 [PMID:18363348] |
| ChEMBL | Inhibition of Photinus pyralis luciferase | B | 5.21 | pIC50 | 6200 | nM | IC50 | J Med Chem (2008) 51: 2372-2386 [PMID:18363348] |
| mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 | B | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (2002) 45: 529-532 [PMID:11784156] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
