ChEMBL ligand: CHEMBL35482
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
Luciferin 4-monooxygenase in Photinus pyralis [ChEMBL: CHEMBL5567] [UniProtKB: P08659] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
COX-1 /Prostaglandin G/H synthase 1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
ChEMBL	Inhibition of MEK1 phosphorylation by activated human recombinant Raf	B	5	pIC50	>10000	nM	IC50	J Med Chem (2002) 45: 529-532 [PMID:11784156]
ChEMBL	Inhibition of MEK1 (unknown origin)	B	5.4	pIC50	4000	nM	IC50	Medchemcomm (2013) 4: 135-139
ChEMBL	Inhibition of Mitogen activated protein kinase kinase 1 (MKK1)	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
ChEMBL	Inhibition of RAF1- induced activation of MEK (unknown origin) signalling pathway assessed as reduction in MEK1 phosphorylation	B	5.73	pIC50	1880	nM	IC50	Bioorg Med Chem (2024) 109: 117791-117791 [PMID:38870715]
mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507]
ChEMBL	Inhibition of MEK2 (unknown origin)	B	4.3	pIC50	50000	nM	IC50	Medchemcomm (2013) 4: 135-139
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate	B	5.74	pIC50	1837	nM	IC50	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
Luciferin 4-monooxygenase in Photinus pyralis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5567] [UniProtKB: P08659]
ChEMBL	Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL	Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay	B	4.22	pIC50	60000	nM	IC50	J Med Chem (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL	Inhibition of Photinus pyralis luciferase by Easy lite assay	B	4.96	pIC50	11000	nM	IC50	J Med Chem (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL	Inhibition of Photinus pyralis luciferase by PK-Light assay	B	5.19	pIC50	6400	nM	IC50	J Med Chem (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL	Inhibition of Photinus pyralis luciferase	B	5.21	pIC50	6200	nM	IC50	J Med Chem (2008) 51: 2372-2386 [PMID:18363348]
mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL	Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1	B	5.55	pIC50	2800	nM	IC50	J Med Chem (2002) 45: 529-532 [PMID:11784156]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
COX-1 /Prostaglandin G/H synthase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibitory activity against Prostaglandin G/H synthase 1 (COX-1)	B	6	pIC50	1000	nM	IC50	J Med Chem (2003) 46: 1478-1483 [PMID:12672248]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]