ChEMBL ligand: CHEMBL35482 (PD-98059)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507] There should be some charts here, you may need to enable JavaScript!
Luciferin 4-monooxygenase in Photinus pyralis [ChEMBL: CHEMBL5567] [UniProtKB: P08659] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibitory activity against Prostaglandin G/H synthase 1 (COX-1)	B	6	pIC50	1000	nM	IC50	J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
ChEMBL	Inhibition of MEK1 phosphorylation by activated human recombinant Raf	B	5	pIC50	>10000	nM	IC50	J Med Chem (2002) 45: 529-532 [PMID:11784156]
ChEMBL	Inhibition of MEK1 (unknown origin)	B	5.4	pIC50	4000	nM	IC50	Medchemcomm (2013) 4: 135-139
ChEMBL	Inhibition of Mitogen activated protein kinase kinase 1 (MKK1)	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507]
ChEMBL	Inhibition of MEK2 (unknown origin)	B	4.3	pIC50	50000	nM	IC50	Medchemcomm (2013) 4: 135-139
Luciferin 4-monooxygenase in Photinus pyralis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5567] [UniProtKB: P08659]
ChEMBL	Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL	Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay	B	4.22	pIC50	60000	nM	IC50	J Med Chem (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL	Inhibition of Photinus pyralis luciferase by Easy lite assay	B	4.96	pIC50	11000	nM	IC50	J Med Chem (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL	Inhibition of Photinus pyralis luciferase by PK-Light assay	B	5.19	pIC50	6400	nM	IC50	J Med Chem (2008) 51: 2372-2386 [PMID:18363348]
ChEMBL	Inhibition of Photinus pyralis luciferase	B	5.21	pIC50	6200	nM	IC50	J Med Chem (2008) 51: 2372-2386 [PMID:18363348]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL	Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1	B	5.55	pIC50	2800	nM	IC50	J Med Chem (2002) 45: 529-532 [PMID:11784156]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]