3M-002 [Ligand Id: 9270] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL512901 (CL-075)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TLR8/Toll-like receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5805] [GtoPdb: 1758] [UniProtKB: Q9NR97]
ChEMBL Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase by HEK-blue reporter gene assay F 5.88 pEC50 1320 nM EC50 J. Med. Chem. (2012) 55: 8137-8151 [PMID:22924757]
GtoPdb Assessed as ability to activate NF-κB in HEK293 cells expressing human TLR8. - 5.88 pEC50 1320 nM EC50 J. Med. Chem. (2012) 55: 8137-51 [PMID:22924757]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]