SAFit2 [Ligand Id: 11482] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3623630 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT2C receptor/5-hydroxytryptamine receptor 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of 5-HT2C | B | 5 | pKi | >10000 | nM | Ki | Data for DCP probe SAFit2 |
| D2 receptor/D(2) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of D2 | B | 5 | pKi | >10000 | nM | Ki | Data for DCP probe SAFit2 |
| H4 receptor/Histamine H4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of H4 | B | 5.47 | pKi | 3382 | nM | Ki | Data for DCP probe SAFit2 |
| FKBP prolyl isomerase 1A/Peptidyl-prolyl cis-trans isomerase FKBP1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] | ||||||||
| ChEMBL | Competitive fluorescence polarization binding assay (FKBP1A) | B | 6.93 | pKd | 116.4 | nM | Kd | Data for DCP probe SAFit2 |
| ChEMBL | NanoBRET assay (FKBP51-NLuc) (FKBP1A) | B | 5.96 | pIC50 | 1103 | nM | IC50 | Data for DCP probe SAFit2 |
| ChEMBL | NanoBRET assay (FKBP12-NLuc) (FKBP1A) | B | 6.11 | pIC50 | 771 | nM | IC50 | Data for DCP probe SAFit2 |
| Peptidyl-prolyl cis-trans isomerase FKBP1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2430] [UniProtKB: P68106] | ||||||||
| ChEMBL | Competitive fluorescence polarization binding assay (FKBP1B) | B | 7.41 | pKd | 38.9 | nM | Kd | Data for DCP probe SAFit2 |
| ChEMBL | NanoBRET assay (FKBP12-NLuc) (FKBP1B) | B | 7.1 | pIC50 | 80 | nM | IC50 | Data for DCP probe SAFit2 |
| Peptidyl-prolyl cis-trans isomerase FKBP2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105949] [UniProtKB: P26885] | ||||||||
| ChEMBL | Competitive fluorescence polarization binding assay (FKBP2) | B | 5.98 | pKd | 1053 | nM | Kd | Data for DCP probe SAFit2 |
| Peptidyl-prolyl cis-trans isomerase FKBP3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4746] [UniProtKB: Q00688] | ||||||||
| ChEMBL | Competitive fluorescence polarization binding assay (FKBP3) | B | 5 | pKd | >10000 | nM | Kd | Data for DCP probe SAFit2 |
| FKBP prolyl isomerase 4/Peptidyl-prolyl cis-trans isomerase FKBP4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790] | ||||||||
| ChEMBL | Competitive fluorescence polarization binding assay (FKBP4) | B | 4.3 | pKd | >50000 | nM | Kd | Data for DCP probe SAFit2 |
| ChEMBL | Binding affinity to FKBP52 (unknown origin) assessed as inhibition constant by fluorescence polarization assay | B | 4.3 | pKi | >50000 | nM | Ki | Eur J Med Chem (2024) 272: 116501-116501 [PMID:38754142] |
| ChEMBL | NanoBRET assay (FKBP12-NLuc) (FKBP4) | B | 5.85 | pIC50 | 1409 | nM | IC50 | Data for DCP probe SAFit2 |
| FKBP prolyl isomerase 5/Peptidyl-prolyl cis-trans isomerase FKBP5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052031] [GtoPdb: 3175] [UniProtKB: Q13451] | ||||||||
| ChEMBL | Competitive fluorescence polarization binding assay (FKBP5) | B | 8.22 | pKd | 6 | nM | Kd | Data for DCP probe SAFit2 |
| GtoPdb | - | - | 8.22 | pKi | 6 | nM | Ki | Nat Chem Biol (2015) 11: 33-7 [PMID:25436518] |
| ChEMBL | Displacement of iFit-FL from FKBP51 (unknown origin) by fluorescence polarization assay | B | 8.22 | pKi | 6 | nM | Ki | J Med Chem (2015) 58: 7796-7806 [PMID:26419422] |
| ChEMBL | Binding affinity to FKBP51 (unknown origin) by competitive fluorescence polarization assay | B | 8.22 | pKi | 6 | nM | Ki | J Med Chem (2016) 59: 2410-2422 [PMID:26954324] |
| ChEMBL | Binding affinity to wild type FKBP51 (unknown origin) assessed as inhibition constant by fluorescence polarization assay | B | 8.22 | pKi | 6 | nM | Ki | Eur J Med Chem (2024) 272: 116501-116501 [PMID:38754142] |
| ChEMBL | NanoBRET assay (FKBP51-NLuc) (FKBP5) | B | 6.31 | pIC50 | 493 | nM | IC50 | Data for DCP probe SAFit2 |
| ChEMBL | NanoBRET assay (FKBP12-NLuc) | B | 6.71 | pIC50 | 195.5 | nM | IC50 | Data for DCP probe SAFit2 |
| σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of Sigma 2 | B | 6.65 | pKi | 226 | nM | Ki | Data for DCP probe SAFit2 |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
