compound 24dd [PMID: 20684603] [Ligand Id: 8550] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1215376
  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
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  • dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2]
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  • dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
GtoPdb - - 8.85 pKi 1.4 nM Ki J Med Chem (2010) 53: 5620-8 [PMID:20684603]
ChEMBL Inhibition of human recombinant DPP4 assessed as Gly-Pro-pNA cleavage B 8.85 pKi 1.4 nM Ki J Med Chem (2010) 53: 5620-5628 [PMID:20684603]
dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2]
GtoPdb - - 6.72 pKi 190 nM Ki J Med Chem (2010) 53: 5620-8 [PMID:20684603]
ChEMBL Inhibition of human DPP9 B 9.72 pKi 0.19 nM Ki J Med Chem (2010) 53: 5620-5628 [PMID:20684603]
dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
GtoPdb - - 6.57 pKi 270 nM Ki J Med Chem (2010) 53: 5620-8 [PMID:20684603]
ChEMBL Inhibition of human DPP8 B 9.57 pKi 0.27 nM Ki J Med Chem (2010) 53: 5620-5628 [PMID:20684603]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]