compound 24dd [PMID: 20684603] [Ligand Id: 8550] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1215376
  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
There should be some charts here, you may need to enable JavaScript!
  • dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2]
There should be some charts here, you may need to enable JavaScript!
  • dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
GtoPdb - - 8.85 pKi 1.4 nM Ki J Med Chem (2010) 53: 5620-8 [PMID:20684603]
ChEMBL Inhibition of human recombinant DPP4 assessed as Gly-Pro-pNA cleavage B 8.85 pKi 1.4 nM Ki J Med Chem (2010) 53: 5620-5628 [PMID:20684603]
dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2]
GtoPdb - - 6.72 pKi 190 nM Ki J Med Chem (2010) 53: 5620-8 [PMID:20684603]
ChEMBL Inhibition of human DPP9 B 9.72 pKi 0.19 nM Ki J Med Chem (2010) 53: 5620-5628 [PMID:20684603]
dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
GtoPdb - - 6.57 pKi 270 nM Ki J Med Chem (2010) 53: 5620-8 [PMID:20684603]
ChEMBL Inhibition of human DPP8 B 9.57 pKi 0.27 nM Ki J Med Chem (2010) 53: 5620-5628 [PMID:20684603]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]