ChEMBL ligand: CHEMBL244888 (Ercefuryl 200, Nifuroxazida, Nifuroxazide, NSC-759261, RC-27109, SJ000287313)
GroEL/GroES in Escherichia coli [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6] There should be some charts here, you may need to enable JavaScript!
myeloperoxidase/Myeloperoxidase in Human [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6]
ChEMBL	Inhibition of Escherichia coli GroEL/ES-mediated refolding of the denatured malate dehydrogenase	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
ChEMBL	Inhibition of Escherichia coli GroEL/ES assessed as inhibition of native malate dehydrogenase treated after denatured malate dehydrogenase completely refold	B	4.2	pIC50	>63000	nM	IC50	Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
ChEMBL	Inhibition of Escherichia coli GroEL/ES assessed as inhibition of native malate dehydrogenase treated after denatured malate dehydrogenase completely refold in presence of NfsB nitroreductase	B	4.25	pIC50	>56000	nM	IC50	Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
ChEMBL	Inhibition of Escherichia coli GroEL/ES-mediated refolding of the denatured malate dehydrogenase in presence of Escherichia coli type 1 NfsB nitroreductase	B	4.72	pIC50	19000	nM	IC50	Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164]
ChEMBL	Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (2017) 60: 6563-6586 [PMID:28671460]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	5.11	pIC50	7820	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ChEMBL	ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye	F	4.82	pEC50	>15000	nM	EC50	Nature (2010) 465: 311-315 [PMID:20485428]
ChEMBL	ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye	F	5.42	pEC50	3772.3	nM	EC50	Nature (2010) 465: 311-315 [PMID:20485428]
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763]
ChEMBL	Inhibition of STAT3 expressed in human U3A cells after 1 hr by luciferase reporter gene assay	B	5.52	pEC50	3000	nM	EC50	J Med Chem (2012) 55: 6645-6668 [PMID:22650325]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]