CyPPA [Ligand Id: 2323] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL453730 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1] | ||||||||
| GtoPdb | - | - | 4.9 | pEC50 | - | - | - | Br J Pharmacol (2007) 151: 655-65 [PMID:17486140] |
| KCa2.2/Small conductance calcium-activated potassium channel protein 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2547] [GtoPdb: 382] [UniProtKB: P70604] | ||||||||
| ChEMBL | Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology | B | 5.13 | pEC50 | 7480 | nM | EC50 | J Med Chem (2022) 65: 303-322 [PMID:34962403] |
| KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6] | ||||||||
| GtoPdb | - | - | 5.3 | pEC50 | - | - | - | Br J Pharmacol (2007) 151: 655-65 [PMID:17486140] |
| KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605] | ||||||||
| ChEMBL | Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells | B | 4.3 | pKi | >50000 | nM | Ki | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
