AC710 [Ligand Id: 8095] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL2206278 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| colony stimulating factor 1 receptor in Human [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
| GtoPdb | - | - | 8.8 | pKd | 1.57 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| colony stimulating factor 1 receptor/Macrophage colony-stimulating factor 1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5570] [GtoPdb: 1806] [UniProtKB: P09581] | ||||||||
| ChEMBL | Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assay | B | 7.33 | pIC50 | 46.3 | nM | IC50 | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
| GtoPdb | - | - | 8.8 | pKd | 1.57 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| ChEMBL | Binding affinity to CSF1R expressed in HEK-293 cells after 1 hr | B | 8.8 | pKd | 1.57 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| ChEMBL | Inhibition of M-CSF-induced FK506 -fussed CSF1R phosphorylation expressed in HEK293 cells after 2 hrs by sandwich ELISA | B | 7.98 | pIC50 | 10.5 | nM | IC50 | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] | ||||||||
| ChEMBL | Binding affinity to PDGFRalpha expressed in HEK-293 cells | B | 8.89 | pKd | 1.3 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| GtoPdb | - | - | 8.89 | pKd | 1.3 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| ChEMBL | Inhibition of PDGFRbeta phosphorylation in human MG63 cells | B | 8.11 | pIC50 | 7.7 | nM | IC50 | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| GtoPdb | - | - | 9 | pKd | 1 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| ChEMBL | Binding affinity to PDGFRbeta expressed in HEK-293 cells | B | 9 | pKd | 1 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| GtoPdb | - | - | 9 | pKd | 1 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| ChEMBL | Binding affinity to KIT expressed in HEK-293 cells | B | 9 | pKd | 1 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| ChEMBL | Inhibition of KIT phosphorylation in human H526 cells | B | 8.92 | pIC50 | 1.2 | nM | IC50 | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| GtoPdb | - | - | 9.3 | pKd | 0.5 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| ChEMBL | Binding affinity to FLT3 expressed in HEK-293 cells after 1 hr | B | 9.3 | pKd | 0.5 | nM | Kd | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
| ChEMBL | Inhibition of FLT3 phosphorylation in human MV4-11 cells | B | 8.7 | pIC50 | 2 | nM | IC50 | ACS Med Chem Lett (2012) 3: 997-1002 [PMID:24900421] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
