SNAP-5114 [Ligand Id: 4677] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL75035 (SNAP-5114)
  • BGT1/Betaine transporter in Human [ChEMBL: CHEMBL3715] [GtoPdb: 932] [UniProtKB: P48065]
  • This target only has 0 pki data point
  • 0
1 CHEMBL75035_lig_chart_1 Betaine transporter Human
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  • DAT/Dopamine transporter in Mouse [ChEMBL: CHEMBL2799] [GtoPdb: 927] [UniProtKB: Q61327]
  • This target only has 0 pki data point
  • 0
2 CHEMBL75035_lig_chart_2 Dopamine transporter Mouse
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3 CHEMBL75035_lig_chart_3 GABA transporter 1 HumanMouse
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  • GAT2/GABA transporter 2 in Human [ChEMBL: CHEMBL4535] [GtoPdb: 930] [UniProtKB: Q9NSD5]
  • BGT1/GABA transporter 2 in Mouse [ChEMBL: CHEMBL4228] [GtoPdb: 932] [UniProtKB: P31651]
  • GAT2/GABA transporter 2 in Rat [ChEMBL: CHEMBL4889] [GtoPdb: 930] [UniProtKB: P31646]
  • This target only has 0 pki data point
  • 0
4 CHEMBL75035_lig_chart_4 GABA transporter 2 HumanMouseRat
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  • GAT3/GABA transporter 3 in Human [ChEMBL: CHEMBL5208] [GtoPdb: 931] [UniProtKB: P48066]
  • GAT2/GABA transporter 3 in Mouse [ChEMBL: CHEMBL5205] [GtoPdb: 930] [UniProtKB: P31649]
  • GAT3/GAT2 in Rat [GtoPdb: 931930] [UniProtKB: P31647P31646]
  • This target only has 0 pki data point
  • 0
5 CHEMBL75035_lig_chart_5 GABA transporter 3 HumanMouseRat
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  • GAT3/GABA transporter 4 in Mouse [ChEMBL: CHEMBL3699] [GtoPdb: 931] [UniProtKB: P31650]
  • This target only has 0 pki data point
  • 0
6 CHEMBL75035_lig_chart_6 GABA transporter 4 Mouse
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  • SERT/Serotonin transporter in Mouse [ChEMBL: CHEMBL4642] [GtoPdb: 928] [UniProtKB: Q60857]
  • This target only has 0 pki data point
  • 0
7 CHEMBL75035_lig_chart_7 Serotonin transporter Mouse
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
BGT1/Betaine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3715] [GtoPdb: 932] [UniProtKB: P48065]
ChEMBL Inhibition of human BGT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis B 4.14 pIC50 71700 nM IC50 Bioorg. Med. Chem. (2013) 21: 4938-4950 [PMID:23886812]
ChEMBL Inhibition of human BGT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis B 4.14 pIC50 71700 nM IC50 ACS Med. Chem. Lett. (2014) 5: 889-893 [PMID:25147609]
DAT/Dopamine transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2799] [GtoPdb: 927] [UniProtKB: Q61327]
ChEMBL Inhibition of mouse GAT3 expressed in HEK293 cells by [3H]GABA uptake assay B 5.3 pIC50 5011.87 nM IC50 Bioorg. Med. Chem. (2015) 23: 1284-1306 [PMID:25698617]
GAT1/GABA transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1903] [GtoPdb: 929] [UniProtKB: P30531]
ChEMBL Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis B 4 pIC50 >100000 nM IC50 ACS Med. Chem. Lett. (2014) 5: 889-893 [PMID:25147609]
GAT1/GABA transporter 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5445] [GtoPdb: 929] [UniProtKB: P31648]
ChEMBL Binding affinity to mouse GAT1 stably transfected in HEK293 cells by NO-711 binding assay B 4.56 pKi 27542.29 nM Ki Bioorg. Med. Chem. (2013) 21: 5154-5167 [PMID:23859778]
ChEMBL Displacement of NO711 from mouse GAT1 expressed in HEK293 cells by LC-MS/MS analysis B 4.56 pKi 27542.29 nM Ki Eur. J. Med. Chem. (2014) 83: 256-273 [PMID:24973660]
ChEMBL Inhibition of [2H10]NO 711 binding to mouse GAT1 expressed in HEK293 cell membranes after 40 mins by LC-ESI-MS-MS analysis B 4.56 pKi 27542.29 nM Ki Bioorg Med Chem (2018) 26: 3668-3687 [PMID:29886082]
ChEMBL Inhibition of mouse GAT1 expressed in HEK cells assessed as reduction in [3H]GABA uptake by measuring remaining [3H]GABA uptake levels preincubated for 25 mins followed by [3H]GABA addition and measured after 4 mins by microbeta liquid scintillation counting analysis B 4.07 pIC50 85113.8 nM IC50 Bioorg Med Chem (2019) 27: 144-152 [PMID:30503411]
ChEMBL Inhibition of mouse GAT1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition measured after 4 mins by liquid scintillation counting analysis B 4.07 pIC50 85113.8 nM IC50 Bioorg Med Chem (2018) 26: 3668-3687 [PMID:29886082]
ChEMBL Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK cells B 4.07 pIC50 85113.8 nM IC50 Eur. J. Med. Chem. (2008) 43: 2404-2411 [PMID:18395300]
ChEMBL Inhibition of GABA uptake at murine GAT-1 expressed in HEK293 cells B 4.07 pIC50 85113.8 nM IC50 Eur. J. Med. Chem. (2013) 65: 487-499 [PMID:23770450]
ChEMBL Inhibition of mouse GAT1-mediated [3H]GABA uptake stably transfected in HEK293 cells B 4.07 pIC50 85113.8 nM IC50 Bioorg. Med. Chem. (2013) 21: 5154-5167 [PMID:23859778]
ChEMBL Inhibition of mouse GAT1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake B 4.07 pIC50 85113.8 nM IC50 Eur. J. Med. Chem. (2014) 83: 256-273 [PMID:24973660]
ChEMBL Inhibition of mouse GAT1 expressed in HEK293 cells by [3H]GABA uptake assay B 4.07 pIC50 85113.8 nM IC50 Bioorg. Med. Chem. (2015) 23: 1284-1306 [PMID:25698617]
ChEMBL Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cells B 4.07 pIC50 85000 nM IC50 Eur. J. Med. Chem. (2011) 46: 1483-1498 [PMID:21353350]
ChEMBL Inhibition of mouse mGAT1 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis B 4.52 pIC50 >30000 nM IC50 Bioorg. Med. Chem. (2015) 23: 2480-2488 [PMID:25882526]
GAT2/GABA transporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4535] [GtoPdb: 930] [UniProtKB: Q9NSD5]
ChEMBL Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis B 4.92 pIC50 11900 nM IC50 Bioorg. Med. Chem. (2013) 21: 4938-4950 [PMID:23886812]
ChEMBL Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis B 4.92 pIC50 11900 nM IC50 ACS Med. Chem. Lett. (2014) 5: 889-893 [PMID:25147609]
BGT1/GABA transporter 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4228] [GtoPdb: 932] [UniProtKB: P31651]
ChEMBL Inhibition of GABA uptake at murine BGT-1 expressed in HEK293 cells B 4.51 pIC50 30902.95 nM IC50 Eur. J. Med. Chem. (2013) 65: 487-499 [PMID:23770450]
ChEMBL Inhibition of mouse mGAT2 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis B 4.66 pIC50 22000 nM IC50 Bioorg. Med. Chem. (2015) 23: 2480-2488 [PMID:25882526]
GAT2/GABA transporter 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4889] [GtoPdb: 930] [UniProtKB: P31646]
ChEMBL Inhibitory activity against rat GABA transporter-2 (rGAT2) B 4.68 pIC50 21000 nM IC50 J. Med. Chem. (1994) 37: 2334-2342 [PMID:8057281]
ChEMBL Inhibition of rat GAT2 assessed as [3H]GABA uptake B 4.68 pIC50 20892.96 nM IC50 Bioorg. Med. Chem. (2011) 19: 6492-6504 [PMID:21940173]
GtoPdb - - 4.7 pIC50 20000 nM IC50 Recept Channels (1994) 2: 207-13 [PMID:7874447]
GAT3/GABA transporter 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5208] [GtoPdb: 931] [UniProtKB: P48066]
ChEMBL Inhibition of human GAT3 assessed as [3H]GABA uptake B 5.3 pIC50 5011.87 nM IC50 Bioorg. Med. Chem. (2011) 19: 6492-6504 [PMID:21940173]
ChEMBL Inhibitory activity against human sodium and chloride dependent GABA transporter 3 B 5.3 pIC50 5000 nM IC50 J. Med. Chem. (1994) 37: 2334-2342 [PMID:8057281]
ChEMBL Binding affinity to GAT3 B 5.3 pIC50 5000 nM IC50 Eur. J. Med. Chem. (2010) 45: 2453-2466 [PMID:20219271]
ChEMBL Inhibition of human GAT3 expressed in COS7 cells assessed as reduction in [2H6]GABA uptake preincubated for 25 mins followed by [2H6]GABA addition and measured after 6 mins by LC-MS/MS analysis B 5.48 pIC50 3311.31 nM IC50 Bioorg Med Chem (2019) 27: 144-152 [PMID:30503411]
ChEMBL Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis B 5.95 pIC50 1120 nM IC50 Bioorg. Med. Chem. (2013) 21: 4938-4950 [PMID:23886812]
ChEMBL Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis B 5.95 pIC50 1120 nM IC50 ACS Med. Chem. Lett. (2014) 5: 889-893 [PMID:25147609]
GAT2/GABA transporter 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5205] [GtoPdb: 930] [UniProtKB: P31649]
ChEMBL Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cells B 4.46 pIC50 35000 nM IC50 Eur. J. Med. Chem. (2011) 46: 1483-1498 [PMID:21353350]
ChEMBL Inhibition of mouse GAT2 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting B 4.66 pIC50 21900 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 417-423 [PMID:26706177]
ChEMBL Inhibition of mouse mGAT3 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis B 4.7 pIC50 20000 nM IC50 Bioorg. Med. Chem. (2015) 23: 2480-2488 [PMID:25882526]
ChEMBL Inhibition of [3H]GABA uptake at mouse GAT3 expressed in HEK cells B 5.29 pIC50 5128.61 nM IC50 Eur. J. Med. Chem. (2008) 43: 2404-2411 [PMID:18395300]
ChEMBL Inhibition of GABA uptake at murine GAT-2 expressed in HEK293 cells B 5.29 pIC50 5128.61 nM IC50 Eur. J. Med. Chem. (2013) 65: 487-499 [PMID:23770450]
ChEMBL Inhibition of mouse GAT3 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake B 5.29 pIC50 5128.61 nM IC50 Eur. J. Med. Chem. (2014) 83: 256-273 [PMID:24973660]
GAT3/GAT2 in Rat [GtoPdb: 931930] [UniProtKB: P31647P31646]
GtoPdb - - 4.7 pIC50 20000 nM IC50 Recept Channels (1994) 2: 207-13 [PMID:7874447]
GAT3/GABA transporter 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3699] [GtoPdb: 931] [UniProtKB: P31650]
ChEMBL Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells B 4.66 pIC50 22000 nM IC50 Eur. J. Med. Chem. (2011) 46: 1483-1498 [PMID:21353350]
ChEMBL Inhibition of mouse GAT3 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting B 5.2 pIC50 6300 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 417-423 [PMID:26706177]
ChEMBL Inhibition of mouse mGAT4 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis B 5.22 pIC50 6000 nM IC50 Bioorg. Med. Chem. (2015) 23: 2480-2488 [PMID:25882526]
ChEMBL Inhibition of mouse GAT3 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition measured after 4 mins by liquid scintillation counting analysis B 5.29 pIC50 5128.61 nM IC50 Bioorg Med Chem (2018) 26: 3668-3687 [PMID:29886082]
ChEMBL Inhibition of mouse GAT3 expressed in HEK cells assessed as reduction in [3H]GABA uptake by measuring remaining [3H]GABA uptake levels preincubated for 25 mins followed by [3H]GABA addition and measured after 4 mins by microbeta liquid scintillation counting analysis B 5.29 pIC50 5128.61 nM IC50 Bioorg Med Chem (2019) 27: 144-152 [PMID:30503411]
ChEMBL Inhibition of mouse GAT4 expressed in HEK cells assessed as reduction in [3H]GABA uptake by measuring remaining [3H]GABA uptake levels preincubated for 25 mins followed by [3H]GABA addition and measured after 4 mins by microbeta liquid scintillation counting analysis B 5.65 pIC50 2238.72 nM IC50 Bioorg Med Chem (2019) 27: 144-152 [PMID:30503411]
ChEMBL Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition and measured after 4 mins by microbeta liquid scintillation counting method B 5.71 pIC50 1949.84 nM IC50 Bioorg Med Chem (2019) 27: 822-831 [PMID:30718063]
ChEMBL Inhibition of GABA uptake at murine GAT-3 expressed in HEK293 cells B 5.71 pIC50 1949.84 nM IC50 Eur. J. Med. Chem. (2013) 65: 487-499 [PMID:23770450]
ChEMBL Inhibition of mouse GAT4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake B 5.71 pIC50 1949.84 nM IC50 Eur. J. Med. Chem. (2014) 83: 256-273 [PMID:24973660]
ChEMBL Inhibition of mouse GAT4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition measured after 4 mins by liquid scintillation counting analysis B 5.71 pIC50 1949.84 nM IC50 Bioorg Med Chem (2018) 26: 3668-3687 [PMID:29886082]
ChEMBL Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition and measured after 4 mins by microbeta liquid scintillation counting method B 5.71 pIC50 1949.84 nM IC50 Bioorg Med Chem (2019) 27: 822-831 [PMID:30718063]
ChEMBL Inhibition of [3H]GABA uptake at mouse GAT4 expressed in HEK cells B 5.81 pIC50 1548.82 nM IC50 Eur. J. Med. Chem. (2008) 43: 2404-2411 [PMID:18395300]
SERT/Serotonin transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4642] [GtoPdb: 928] [UniProtKB: Q60857]
ChEMBL Inhibition of mouse GAT4 expressed in HEK293 cells by [3H]GABA uptake assay B 5.81 pIC50 1548.82 nM IC50 Bioorg. Med. Chem. (2015) 23: 1284-1306 [PMID:25698617]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]