ChEMBL ligand: CHEMBL443684 (A-855071.0, ABT-263, Navitoclax)
BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415] There should be some charts here, you may need to enable JavaScript!
Bcl-2-like 2/Apoptosis regulator Bcl-W in Human [ChEMBL: CHEMBL4677] [GtoPdb: 2846] [UniProtKB: Q92843] There should be some charts here, you may need to enable JavaScript!
Bcl-2-like 1/Apoptosis regulator Bcl-X in Human [ChEMBL: CHEMBL4625] [GtoPdb: 2845] [UniProtKB: Q07817] There should be some charts here, you may need to enable JavaScript!
Aspartyl/asparaginyl beta-hydroxylase in Human [ChEMBL: CHEMBL4680030] [UniProtKB: Q12797] There should be some charts here, you may need to enable JavaScript!
Bcl2-antagonist of cell death (BAD) in Human [ChEMBL: CHEMBL3817] [UniProtKB: Q92934] There should be some charts here, you may need to enable JavaScript!
MCL1 apoptosis regulator, BCL2 family member/Induced myeloid leukemia cell differentiation protein Mcl-1 in Human [ChEMBL: CHEMBL4361] [GtoPdb: 2847] [UniProtKB: Q07820] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415]
ChEMBL	Binding affinity to human full-length N-terminal His6-tagged prephosphorylated Bcl2 (2 to 206 residues) expressed in Escherichia coli S12 extract by isothermal titration calorimetry	B	5.74	pKd	1803	nM	Kd	J Med Chem (2020) 63: 13733-13744 [PMID:33197310]
ChEMBL	Binding affinity to human full-length N-terminal His6-tagged Bcl2 (2 to 206 residues) expressed in Escherichia coli S12 extract by isothermal titration calorimetry	B	7.69	pKd	20.6	nM	Kd	J Med Chem (2020) 63: 13733-13744 [PMID:33197310]
ChEMBL	Displacement of biotin-tagged MRPEPATIAQELRRIGDEFNA from C-terminal His-tagged human BCL-2 (1` to 211 residues) expressed in Escherichia coli measured after 2 hrs by AlphaScreen assay	B	9.19	pKd	0.65	nM	Kd	J Med Chem (2021) 64: 14230-14246 [PMID:34533954]
GtoPdb	-	-	9	pKi	<1	nM	Ki	J Med Chem (2008) 51: 6902-15 [PMID:18841882]
ChEMBL	Inhibition of Flu-Bax peptide binding to Bcl2 (unknown origin) by time-resolved fluorescence resonance energy transfer assay	B	9	pKi	<1	nM	Ki	Eur J Med Chem (2019) 177: 63-75 [PMID:31129454]
ChEMBL	Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization assay	B	9	pKi	<1	nM	Ki	Bioorg Med Chem Lett (2016) 26: 2105-2114 [PMID:26988306]
ChEMBL	Binding affinity to BCL2 (unknown origin) by fluorescence polarization assay	B	9	pKi	<1	nM	Ki	Medchemcomm (2016) 7: 778-787
ChEMBL	Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay	B	9	pKi	<1	nM	Ki	Eur J Med Chem (2018) 146: 471-482 [PMID:29407973]
ChEMBL	Displacement of fluorescein labeled Bax peptide from Bcl2 by fluorescence polarization assay	B	9	pKi	<1	nM	Ki	J Med Chem (2008) 51: 6902-6915 [PMID:18841882]
ChEMBL	Inhibition of BCL2 (unknown origin) by TR-FRET assay	B	9.3	pKi	<0.5	nM	Ki	J Med Chem (2020) 63: 11420-11435 [PMID:32539387]
ChEMBL	Inhibition of Bcl2 (unknown origin)	B	10.36	pKi	0.04	nM	Ki	J Med Chem (2019) 62: 10005-10025 [PMID:31188592]
ChEMBL	Inhibition of Bcl2 (unknown origin)	B	10.36	pKi	0.04	nM	Ki	J Med Chem (2018) 61: 2636-2651 [PMID:28926247]
ChEMBL	Inhibition of BCL-2 (unknown origin) by fluorescence polarization assay	B	11	pKi	<0.01	nM	Ki	Eur J Med Chem (2019) 167: 76-95 [PMID:30769242]
ChEMBL	Inhibition of human BCL-2 overexpressed in mouse FDC-P1 cells assessed as cell viability after 24 hrs by Cell Titer Glo assay	B	7.82	pIC50	<15	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3026-3033 [PMID:24881567]
ChEMBL	Displacement of Bax-derived peptide from Bcl-2 (unknown origin) by fluorescence polarization assay	B	7.99	pIC50	10.3	nM	IC50	Bioorg Med Chem (2018) 26: 443-454 [PMID:29229225]
ChEMBL	Inhibition of recombinant human C-terminal 6xHis-tagged Bcl-2 (M1 to F212 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM peptide as substrate incubated for 120 to 180 mins by TR-FRET assay	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126682-126682 [PMID:31606346]
Bcl-2-like 2/Apoptosis regulator Bcl-W in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4677] [GtoPdb: 2846] [UniProtKB: Q92843]
ChEMBL	Inhibition of BCL-W (unknown origin) by fluorescence polarization assay	B	6.61	pKi	245	nM	Ki	Eur J Med Chem (2019) 167: 76-95 [PMID:30769242]
ChEMBL	Inhibition of recombinant human N-terminal 6xHis-tagged Bcl-w (M1 to R171) expressed in Escherichia coli using HyLite Fluor 647-labeled Bim peptide as substrate incubated for 120 to 180 mins by TR-FRET assay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126682-126682 [PMID:31606346]
Bcl-2-like 1/Apoptosis regulator Bcl-X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4625] [GtoPdb: 2845] [UniProtKB: Q07817]
ChEMBL	Displacement of biotin-tagged LWAAQRYGRELRRMSDEFEGSFKGL from human BCL-XL expressed in Escherichia coli measured after 2 hrs by AlphaScreen assay	B	8.68	pKd	2.07	nM	Kd	J Med Chem (2021) 64: 14230-14246 [PMID:34533954]
ChEMBL	Inhibition of BCL-XL (unknown origin) by fluorescence polarization assay	B	7.32	pKi	48	nM	Ki	Eur J Med Chem (2019) 167: 76-95 [PMID:30769242]
ChEMBL	Binding affinity to Bcl-xl	B	7.44	pKi	36	nM	Ki	J Med Chem (2010) 53: 6779-6810 [PMID:20925433]
GtoPdb	-	-	9	pKi	<1	nM	Ki	J Med Chem (2008) 51: 6902-15 [PMID:18841882]
ChEMBL	Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assay	B	9	pKi	<1	nM	Ki	Eur J Med Chem (2018) 146: 471-482 [PMID:29407973]
ChEMBL	Binding affinity to Bcl-xL by competitive fluorescence polarization assay	B	9	pKi	<1	nM	Ki	J Med Chem (2010) 53: 2577-2588 [PMID:20192224]
ChEMBL	Binding affinity to Bcl-XL (unknown origin) by fluorescence polarization assay	B	9	pKi	<1	nM	Ki	Bioorg Med Chem Lett (2016) 26: 2105-2114 [PMID:26988306]
ChEMBL	Binding affinity to Bcl-XL (unknown origin) by fluorescence polarization assay	B	9.3	pKi	<0.5	nM	Ki	Medchemcomm (2016) 7: 778-787
ChEMBL	Inhibition of Flu-Bax peptide binding to Bcl-xL (unknown origin) by time-resolved fluorescence resonance energy transfer assay	B	9.3	pKi	<0.5	nM	Ki	Eur J Med Chem (2019) 177: 63-75 [PMID:31129454]
ChEMBL	Inhibition of F-Bak binding to GST-tagged BCL-XL (unknown origin) measured after 1 hr by TR-FRET assay	B	10	pKi	<0.1	nM	Ki	ACS Med Chem Lett (2021) 12: 1011-1016 [PMID:34141086]
ChEMBL	Inhibition of Bcl-xL (unknown origin)	B	10.26	pKi	0.06	nM	Ki	J Med Chem (2018) 61: 2636-2651 [PMID:28926247]
ChEMBL	Inhibition of human BCL-xL overexpressed in mouse FDC-P1 cells assessed as cell viability after 24 hrs by Cell Titer Glo assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3026-3033 [PMID:24881567]
ChEMBL	Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM peptide as substrate incubated for 120 to 180 mins by TR-FRET assay	B	8.1	pIC50	<8	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126682-126682 [PMID:31606346]
ChEMBL	Displacement of FITC-Bid from GST-tagged human Bcl-xL expressed in Escherichia coli after 2 hrs by TR-FRET assay	B	8.48	pIC50	3.3	nM	IC50	J Med Chem (2013) 56: 9635-9645 [PMID:24215352]
Aspartyl/asparaginyl beta-hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4680030] [UniProtKB: Q12797]
ChEMBL	Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with high 200 uM 2OG, 100 uM L-ascorbic acid and 2 uM FAS incubated for 35 mins by MS analysis	B	5.88	pIC50	1330	nM	IC50	Bioorg Med Chem (2020) 28: 115675-115675 [PMID:33069066]
ChEMBL	Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using high 10 uM hFX-CP as substrate mixture with 10 uM 2OG, 100 uM L-ascorbic acid and 2 uM FAS incubated for 35 mins by MS analysis	B	5.92	pIC50	1210	nM	IC50	Bioorg Med Chem (2020) 28: 115675-115675 [PMID:33069066]
ChEMBL	Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with 3 uM 2OG, 100 uM L-ascorbic acid and 2 uM FAS incubated for 35 mins by MS analysis	B	5.99	pIC50	1030	nM	IC50	Bioorg Med Chem (2020) 28: 115675-115675 [PMID:33069066]
ChEMBL	Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with 3 uM 2OG, 100 uM L-ascorbic acid and high 20 uM FAS incubated for 35 mins by MS analysis	B	6.1	pIC50	800	nM	IC50	Bioorg Med Chem (2020) 28: 115675-115675 [PMID:33069066]
Bcl2-antagonist of cell death (BAD) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3817] [UniProtKB: Q92934]
ChEMBL	Displacement of fluorescein labeled BAD peptide from Bcl-XL by fluorescence polarization assay	B	9	pKi	<1	nM	Ki	J Med Chem (2008) 51: 6902-6915 [PMID:18841882]
ChEMBL	Binding affinity to BH3 binding groove of BclXL	B	9.3	pKi	<0.5	nM	Ki	J Med Chem (2008) 51: 3661-3680 [PMID:18457385]
MCL1 apoptosis regulator, BCL2 family member/Induced myeloid leukemia cell differentiation protein Mcl-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4361] [GtoPdb: 2847] [UniProtKB: Q07820]
ChEMBL	Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assay	B	6.26	pKi	550	nM	Ki	Eur J Med Chem (2018) 146: 471-482 [PMID:29407973]
ChEMBL	Inhibition of F-Bak binding to GST-tagged MCL1 (unknown origin) measured after 1 hr by TR-FRET assay	B	6.65	pKi	>224	nM	Ki	ACS Med Chem Lett (2021) 12: 1011-1016 [PMID:34141086]
ChEMBL	Inhibition of Flu-Bax peptide binding to MCl-1 (unknown origin) by time-resolved fluorescence resonance energy transfer assay	B	9	pKi	<1	nM	Ki	Eur J Med Chem (2019) 177: 63-75 [PMID:31129454]
ChEMBL	Displacement of FITC-Bid from GST-tagged human Mcl-1 expressed in Escherichia coli after 2 hrs by TR-FRET assay	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2013) 56: 9635-9645 [PMID:24215352]
ChEMBL	Inhibition of recombinant human C-terminal 6xHis-tagged Mcl-1 (E171 ti G327) expressed in Escherichia coli using biotin-labeled BIM peptide as substrate incubated for 120 to 180 mins by TR-FRET assay	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126682-126682 [PMID:31606346]
ChEMBL	Binding affinity to MCL1 (unknown origin) by fluorescence polarization assay	B	6.3	pIC50	500	nM	IC50	Medchemcomm (2016) 7: 778-787

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]