Bcl-2-like 2 | B-cell lymphoma 2 (Bcl-2) protein family | IUPHAR/BPS Guide to PHARMACOLOGY

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Bcl-2-like 2

target has curated data in GtoImmuPdb

Target id: 2846

Nomenclature: Bcl-2-like 2

Abbreviated Name: Bcl-w

Family: B-cell lymphoma 2 (Bcl-2) protein family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 192 14q11.2-q12 BCL2L2 BCL2 like 2
Mouse - 193 14 C3 Bcl2l2 BCL2-like 2
Rat - 193 15p13 Bcl2l2 Bcl2-like 2
Previous and Unofficial Names
BCL2-like 2
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ABT-737 Hs Antagonist >9.0 pKi 1
pKi >9.0 (Ki <1x10-9 M) [1]
venetoclax Hs Antagonist 6.6 pKi 2
pKi 6.6 (Ki 2.45x10-7 M) [2]
Immunopharmacology Comments
The role of Bcl-2 family members in immunity and disease is reviewed in [5]. Pharmacological inhibition of Bcl-2 family proteins reduces disease severity in several animal models of autoimmunity; see ligand ABT-737 [1].


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1. Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC et al.. (2007) Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J. Med. Chem., 50 (4): 641-62. [PMID:17256834]

2. Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, Dayton BD, Ding H, Enschede SH, Fairbrother WJ et al.. (2013) ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med., 19 (2): 202-8. [PMID:23291630]

How to cite this page

B-cell lymphoma 2 (Bcl-2) protein family: Bcl-2-like 2. Last modified on 31/01/2017. Accessed on 11/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2846.