(+)-ADTN [Ligand Id: 932] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL26736
  • D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
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  • D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
GtoPdb - - 6.4 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666];
Nature (1991) 350: 614-9 [PMID:1826762]
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL Affinity for Dopamine receptor D1 binding sites was evaluated in a test involving displacement of [3H]- fenoldopam in rat striatum B 7.15 pKd 0.07 uM K Bind J Med Chem (1986) 29: 1615-1627 [PMID:2875183]
Dopamine D2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
ChEMBL Affinity for Dopamine receptor D2 was evaluated from the ability to displace [3H]spiroperidol from homogenized bovine pituitary B 6.68 pKd 0.21 uM K Bind J Med Chem (1986) 29: 1615-1627 [PMID:2875183]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligand B 7.18 pKi 65.7 nM Ki J Med Chem (1990) 33: 171-178 [PMID:2136916]
ChEMBL Inhibition of specific binding of [3H]spiroperidol to Dopamine receptor D2 in rat striatal membranes B 6.15 pIC50 700 nM IC50 J Med Chem (1998) 41: 4165-4170 [PMID:9767652]
D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918]
GtoPdb - - 6 pKi - - - Nature (1991) 350: 614-9 [PMID:1826762]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]