inhibitor 19 [PMID: 21476495] [Ligand Id: 8621] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1782887
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  • Leucyl-cysteinyl aminopeptidase/Cystinyl aminopeptidase in Human [ChEMBL: CHEMBL2693] [GtoPdb: 1570] [UniProtKB: Q9UIQ6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Aminopeptidase N in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144]
ChEMBL Inhibition of catalytic activity of recombinant human AP-N transfected in human HEK-293 cells assessed as cleavage of substrate L-leucine-p-nitroanilide to L-leucine and p-nitroaniline measured every 5 mins for 10 to 50 mins by spectrophotometric analysis B 6.62 pKi 240 nM Ki J Med Chem (2011) 54: 3779-3792 [PMID:21476495]
Leucyl-cysteinyl aminopeptidase/Cystinyl aminopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2693] [GtoPdb: 1570] [UniProtKB: Q9UIQ6]
GtoPdb - - 8.74 pKi 1.8 nM Ki J Med Chem (2011) 54: 3779-92 [PMID:21476495]
ChEMBL Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as cleavage of substrate L-leucine-p-nitroanilide to L-leucine and p-nitroaniline measured every 5 mins for 10 to 50 mins by spectrophotometric analysis B 8.74 pKi 1.8 nM Ki J Med Chem (2011) 54: 3779-3792 [PMID:21476495]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]