ChEMBL ligand: CHEMBL102714 (SB-216763)
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7]
ChEMBL	Inhibition of CDK1/cyclinB	B	6.26	pIC50	550	nM	IC50	Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396]
ChEMBL	Inhibition of human CDK2/Cyclin A by ELISA	B	6.57	pIC50	269	nM	IC50	J Med Chem (2010) 53: 994-1003 [PMID:20030405]
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385]
ChEMBL	Inhibition of human CDK4/cyclin D1 by ELISA	B	4.49	pIC50	32000	nM	IC50	J Med Chem (2010) 53: 994-1003 [PMID:20030405]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL	Inhibition of GSK3alpha	B	7.47	pIC50	34	nM	IC50	Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249]
GtoPdb	-	-	8.05	pIC50	9	nM	IC50	Chem Biol (2000) 7: 793-803 [PMID:11033082]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of GSK3-beta after 30 mins by luminescence assay	B	7.04	pIC50	92	nM	IC50	Bioorg Med Chem (2010) 18: 6785-6795 [PMID:20708937]
ChEMBL	Competitive inhibition of human recombinant full length GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated with enzyme for 10 mins followed by substrate and 25 uM ATP addition measured after 60 mins by ADP-Glo luminescence assay	B	7.05	pIC50	89	nM	IC50	Eur J Med Chem (2019) 175: 309-329 [PMID:31096153]
ChEMBL	Inhibition of human GSK3-beta by scintillation counting	B	7.3	pIC50	50	nM	IC50	J Med Chem (2009) 52: 1853-1863 [PMID:19338355]
ChEMBL	Inhibition of human recombinant GSK3-beta	B	7.32	pIC50	48	nM	IC50	J Med Chem (2010) 53: 994-1003 [PMID:20030405]
ChEMBL	Inhibition of human GSK3-beta	B	7.47	pIC50	34	nM	IC50	Eur J Med Chem (2009) 44: 2361-2371 [PMID:18929433]
ChEMBL	Inhibition of GSK3beta (unknown origin)	B	7.47	pIC50	34	nM	IC50	Eur J Med Chem (2021) 210: 112949-112949 [PMID:33097303]
ChEMBL	Inhibition of GSK3beta (unknown origin)	B	7.47	pIC50	34	nM	IC50	Eur J Med Chem (2017) 125: 464-477 [PMID:27689729]
ChEMBL	Inhibition of GSK3beta (unknown origin) expressed in Sf9 cells using GS1 as substrate and [gamma32]ATP after 30 min by scinitllation counting	B	7.47	pIC50	33.88	nM	IC50	Med Chem Res (2007) 16: 461-467
ChEMBL	Inhibition of human recombinant N-terminal His-tagged GSK3beta expressed in Escherichia coli using RRRPASVPPSPSLS RHS(pS)HQRR as substrate incubated for 30 mins in presence of ATP by Kinase-Glo reagent based luminescence assay	B	7.54	pIC50	29	nM	IC50	Eur J Med Chem (2021) 223: 113663-113663 [PMID:34198150]
ChEMBL	Inhibition of recombinant human N-terminal His6-tagged GSK3beta H350L mutant expressed in baculovirus infected Sf21 cells using prephosphorylated polypeptide as substrate incubated for 1 min followed by substrate addition and measured after 30 mins by Kinase-Glo luminescence assay	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2021) 30: 115940-115940 [PMID:33340937]
ChEMBL	Inhibition of recombinant human N-terminal His6-tagged GSK-3beta H350L mutant expressed in baculovirus infected Sf21 cells using GSM as substrate incubated for 30 mins in presence of ATP by kinase-glo luminescence assay	B	7.7	pIC50	19.8	nM	IC50	Eur J Med Chem (2020) 207: 112751-112751 [PMID:32950908]
ChEMBL	Inhibition of GSK3beta (unknown origin) pre-incubated for 30 mins followed by ULight-GS (Ser641/pSer657) peptide substrate addition and measured after 1 hr by TR-FRET assay	B	7.94	pIC50	11.4	nM	IC50	J Med Chem (2018) 61: 7640-7656 [PMID:30078314]
ChEMBL	Inhibition of GSK3beta (unknown origin) pre-incubated for 30 mins followed by ULight-GS (Ser641/pSer657) peptide substrate addition and measured after 1 hr by TR-FRET assay	B	7.94	pIC50	11.4	nM	IC50	Eur J Med Chem (2019) 163: 394-402 [PMID:30530190]
ChEMBL	Inhibition of GSK3beta (unknown origin)	B	8.05	pIC50	9	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1532-1537 [PMID:24560539]
ChEMBL	Inhibition of GSK3beta	B	8.05	pIC50	9	nM	IC50	J Med Chem (2012) 55: 9107-9119 [PMID:22489897]
GtoPdb	-	-	8.05	pIC50	~9	nM	IC50	Chem Biol (2000) 7: 793-803 [PMID:11033082]
ChEMBL	Inhibition of recombinant human GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate measured after 60 mins by ADP-Glo luminescence assay	B	8.08	pIC50	8.35	nM	IC50	Bioorg Med Chem (2019) 27: 1804-1817 [PMID:30902399]
ChEMBL	Inhibition of Glycogen synthase kinase-3 beta	B	8.15	pIC50	7	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3049-3053 [PMID:12941331]
ChEMBL	Effective concentration of compound against glycogen synthase kinase-3 in HEK293 cells	F	6.7	pEC50	200	nM	EC50	Bioorg Med Chem Lett (2004) 14: 3245-3250 [PMID:15149684]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	4.8	pIC50	15848.93	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]