compound 1 [PMID: 10498202] [Ligand Id: 6541] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL81927 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] | ||||||||
| ChEMBL | Inhibition of cathepsin D (unknown origin) | B | 9.15 | pKi | 0.7 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 4141-4150 [PMID:25086681] |
| ChEMBL | Inhibition of human liver Cathepsin D using (Ac-Glu-Glu(Edans)-Lys-Pro-Ile-Cys-Phe-PheArg-Leu-Gly-Lys(Dabcyl)-Glu-NH2) peptide as substrate by fluorometric analysis | B | 9.15 | pKi | 0.7 | nM | Ki | Bioorg Med Chem (2021) 29: 115879-115879 [PMID:33271453] |
| ChEMBL | Binding affinity af the compound towards cathepsin D | B | 10.15 | pKi | 0.07 | nM | Ki | J Med Chem (2005) 48: 6607-6619 [PMID:16220977] |
| ChEMBL | Inhibition of cathepsin D (unknown origin) | B | 7.07 | pIC50 | 85 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4141-4150 [PMID:25086681] |
| ChEMBL | Inhibitory activity against human liver Cathepsin D using Cathepsin D assay. | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 2531-2536 [PMID:10498202] |
| GtoPdb | - | - | 9.2 | pIC50 | 0.7 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 2531-6 [PMID:10498202] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
