compound 1 [PMID: 10498202] [Ligand Id: 6541] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL81927 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] | ||||||||
| ChEMBL | Inhibition of cathepsin D (unknown origin) | B | 9.15 | pKi | 0.7 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 4141-4150 [PMID:25086681] |
| ChEMBL | Inhibition of human liver Cathepsin D using (Ac-Glu-Glu(Edans)-Lys-Pro-Ile-Cys-Phe-PheArg-Leu-Gly-Lys(Dabcyl)-Glu-NH2) peptide as substrate by fluorometric analysis | B | 9.15 | pKi | 0.7 | nM | Ki | Bioorg Med Chem (2021) 29: 115879-115879 [PMID:33271453] |
| ChEMBL | Binding affinity af the compound towards cathepsin D | B | 10.15 | pKi | 0.07 | nM | Ki | J Med Chem (2005) 48: 6607-6619 [PMID:16220977] |
| ChEMBL | Inhibition of cathepsin D (unknown origin) | B | 7.07 | pIC50 | 85 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4141-4150 [PMID:25086681] |
| ChEMBL | Inhibitory activity against human liver Cathepsin D using Cathepsin D assay. | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 2531-2536 [PMID:10498202] |
| GtoPdb | - | - | 9.2 | pIC50 | 0.7 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 2531-6 [PMID:10498202] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
