necrostatin-1s [Ligand Id: 9751] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL381230 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546] | ||||||||
| GtoPdb | Affinity constant measured at 37oC. | - | 7.43 | pKd | 37 | nM | Kd | Proc Natl Acad Sci USA (1998) 95: 11211-6 [PMID:9736715] |
| ChEMBL | Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assay | B | 6.12 | pIC50 | 754 | nM | IC50 | J Med Chem (2018) 61: 1895-1920 [PMID:29437386] |
| ChEMBL | Inhibition of RIPK1 (1 to 312 residues) (unknown origin) preincubated for 15 mins followed by addition of [gamma32P] ATP and measured after 30 mins by SDS-PAGE based autoradiography | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (2020) 63: 1490-1510 [PMID:31622096] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
