necrostatin-1s [Ligand Id: 9751] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL381230 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546] | ||||||||
| GtoPdb | Affinity constant measured at 37oC. | - | 7.43 | pKd | 37 | nM | Kd | Proc Natl Acad Sci USA (1998) 95: 11211-6 [PMID:9736715] |
| ChEMBL | Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assay | B | 6.12 | pIC50 | 754 | nM | IC50 | J Med Chem (2018) 61: 1895-1920 [PMID:29437386] |
| ChEMBL | Inhibition of RIPK1 (1 to 312 residues) (unknown origin) preincubated for 15 mins followed by addition of [gamma32P] ATP and measured after 30 mins by SDS-PAGE based autoradiography | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (2020) 63: 1490-1510 [PMID:31622096] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
