4α-PDD [Ligand Id: 2500] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL118987 (4Alpha-Phorbol-Didecanoate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPV4 in Human [GtoPdb: 510] [UniProtKB: Q9HBA0] | ||||||||
| GtoPdb | - | - | 6.5 | pEC50 | - | - | - | Br J Pharmacol (2003) 140: 413-21 [PMID:12970074] |
| TRPV4/Transient receptor potential cation channel subfamily V member 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6126] [GtoPdb: 510] [UniProtKB: Q9EPK8] | ||||||||
| ChEMBL | Activation of mouse TRPV4 Y556A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 5.2 | pEC50 | 6300 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| ChEMBL | Activation of mouse TRPV4 W586A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 5.22 | pEC50 | >6000 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| ChEMBL | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 6.43 | pEC50 | 370 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| ChEMBL | Agonist activity at mouse TRPV4 | B | 6.43 | pEC50 | 370 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 127022-127022 [PMID:32063431] |
| ChEMBL | Activation of mouse TRPV4 S557A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 6.49 | pEC50 | 320 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| GtoPdb | - | - | 6.7 | pEC50 | - | - | - | J Biol Chem (2002) 277: 13569-77 [PMID:11827975] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
