mycophenolic acid [Ligand Id: 6832] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL866 (Mycophenolate mofetil impurity, mycophenolic acid-, Mycophenolic acid, RS-61443 [AS MOFETIL], 68618, NSC-129185, Myfortic)
  • Inosine-5`-monophosphate dehydrogenase in Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /ATCC MYA-565) (Filobasidiella neoformans) [ChEMBL: CHEMBL4295605] [UniProtKB: Q5KP44]
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  • inosine monophosphate dehydrogenase 1/Inosine-5`-monophosphate dehydrogenase 1 in Human [ChEMBL: CHEMBL1822] [GtoPdb: 2624] [UniProtKB: P20839]
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  • inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Inosine-5`-monophosphate dehydrogenase in Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /ATCC MYA-565) (Filobasidiella neoformans) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295605] [UniProtKB: Q5KP44]
ChEMBL Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD B 6.92 pIC50 120 nM IC50 Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754]
inosine monophosphate dehydrogenase 1/Inosine-5`-monophosphate dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1822] [GtoPdb: 2624] [UniProtKB: P20839]
ChEMBL Inhibition of human IMPDH 1 B 7.4 pKi 40 nM Ki J. Med. Chem. (2007) 50: 6685-6691 [PMID:18038969]
ChEMBL Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I) B 7.4 pKi 40 nM Ki J. Med. Chem. (2002) 45: 703-712 [PMID:11806722]
ChEMBL Inhibition of human IMPDH1 B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2008) 16: 9340-9345 [PMID:18809333]
ChEMBL Inhibition of human IMP dehydrogenase 1 B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2008) 16: 7462-7469 [PMID:18583139]
ChEMBL Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I isoform); Range is 33-37 nM B 7.48 pKi 33 nM Ki J. Med. Chem. (1998) 41: 618-622 [PMID:9484510]
ChEMBL Inhibition of human IMPDH type 1 B 7.48 pKi 33 nM Ki J. Med. Chem. (2007) 50: 5743-5751 [PMID:17958343]
ChEMBL Inhibition of human IMPDH1 by Spectrophotometry B 7.48 pKi 33 nM Ki Bioorg. Med. Chem. (2011) 19: 1594-1605 [PMID:21324702]
ChEMBL Inhibition of recombinant human His-tagged IMPDH1 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD B 6.59 pIC50 260 nM IC50 Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754]
ChEMBL Inhibitory activity against inosine monophosphate dehydrogenase IMPDH type I B 7.26 pIC50 55 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 543-546 [PMID:12565968]
ChEMBL Inhibition of human IMPDH1 B 7.49 pIC50 32 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 3479-3483 [PMID:16621550]
ChEMBL In vitro inhibition of inosine Inosine-5'-monophosphate dehydrogenase B 7.7 pIC50 20 nM IC50 J. Med. Chem. (1990) 33: 833-838 [PMID:1967654]
GtoPdb Reference does not distinguish which enzyme isoform is assayed - 7.7 pIC50 20 nM IC50 J Med Chem (1990) 33: 833-8 [PMID:1967654]
ChEMBL Inhibition of human IMPDH1 expressed in Escherichia coli strain BL21(DE3) after 60 mins B 7.72 pIC50 19 nM IC50 Bioorg. Med. Chem. (2010) 18: 8106-8111 [PMID:20934342]
inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268]
ChEMBL Inhibition of human IMPDH 2 B 8 pKi 10 nM Ki J. Med. Chem. (2007) 50: 6685-6691 [PMID:18038969]
ChEMBL Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) B 8 pKi 10 nM Ki J. Med. Chem. (2002) 45: 703-712 [PMID:11806722]
ChEMBL Inhibition of human IMPDH2 B 8 pKi 10 nM Ki Bioorg. Med. Chem. (2008) 16: 9340-9345 [PMID:18809333]
ChEMBL Inhibition of human IMP dehydrogenase 2 B 8 pKi 10 nM Ki Bioorg. Med. Chem. (2008) 16: 7462-7469 [PMID:18583139]
ChEMBL Inhibition of human IMPDH type 2 B 8.15 pKi 7 nM Ki J. Med. Chem. (2007) 50: 5743-5751 [PMID:17958343]
ChEMBL Inhibition of human IMPDH2 by Spectrophotometer B 8.15 pKi 7 nM Ki Bioorg. Med. Chem. (2011) 19: 1594-1605 [PMID:21324702]
ChEMBL Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II isoform); Range is 6-10 nM B 8.22 pKi 6 nM Ki J. Med. Chem. (1998) 41: 618-622 [PMID:9484510]
ChEMBL Inhibition of IMPDH2 B 5.82 pIC50 1500 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 53-56 [PMID:22172700]
ChEMBL Inhibition of IMPDH2 using inosine 5'-monophosphate as substrate by spectrophotometry B 6.2 pIC50 630 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3332-3335 [PMID:22464133]
ChEMBL Inhibition of human IMPDH2 using IMP as substrate in presence of NAD+ after 30 mins B 6.6 pIC50 250 nM IC50 Eur J Med Chem (2018) 158: 286-301 [PMID:30223117]
ChEMBL Inhibition of recombinant human His-tagged IMPDH2 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD B 6.96 pIC50 110 nM IC50 Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754]
ChEMBL Compound was tested for inhibition of human recombinant type II Inosine Monophosphate Dehydrogenase at pH 7.4 B 7.6 pIC50 25.1 nM IC50 J. Med. Chem. (1996) 39: 4181-4196 [PMID:8863796]
ChEMBL Compound was tested for inhibition of human recombinant type II Inosine Monophosphate Dehydrogenase at pH 8.0 B 7.61 pIC50 24.8 nM IC50 J. Med. Chem. (1996) 39: 4181-4196 [PMID:8863796]
GtoPdb Reference does not distinguish which enzyme isoform is assayed - 7.7 pIC50 20 nM IC50 J Med Chem (1990) 33: 833-8 [PMID:1967654]
ChEMBL Inhibition of human IMPDH2 B 7.8 pIC50 16 nM IC50 J. Med. Chem. (2007) 50: 3730-3742 [PMID:17585753]
ChEMBL In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2. B 7.82 pIC50 15 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 2931-2934 [PMID:12270177]
ChEMBL Inhibition of Inosine Monophosphate Dehydrogenase II (IMPDH II) B 7.82 pIC50 15 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 3125-3128 [PMID:12372516]
ChEMBL Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme B 7.82 pIC50 15 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 3557-3560 [PMID:14505670]
ChEMBL Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determined B 7.82 pIC50 15 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 3305-3308 [PMID:12392738]
ChEMBL Inhibition of human Inosine-5'-monophosphate dehydrogenase 2 B 7.82 pIC50 15 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 2137-2140 [PMID:12127522]
ChEMBL Inhibition of human inosine monophosphate dehydrogenase IMPDH II B 7.85 pIC50 14 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 543-546 [PMID:12565968]
ChEMBL Inhibitory activity against inosine monophosphate dehydrogenase IMPDH II B 7.85 pIC50 14 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 547-551 [PMID:12565969]
ChEMBL Inhibition of human inosine-5'-monophosphate dehydrogenase 2 B 7.85 pIC50 14 nM IC50 J. Med. Chem. (2002) 45: 2127-2130 [PMID:12014950]
ChEMBL Inhibition of human IMPDH2 expressed in Escherichia coli strain BL21(DE3) after 60 mins B 7.92 pIC50 12 nM IC50 Bioorg. Med. Chem. (2010) 18: 8106-8111 [PMID:20934342]
ChEMBL Inhibition of human IMPDH2 B 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 3479-3483 [PMID:16621550]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells F 6 pIC50 1000 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection F 5.3 pIC50 >5000 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]