ChEMBL ligand: CHEMBL866 (68618, Mycophenolate, Mycophenolate mofetil impurity, mycophenolic acid-, Mycophenolic acid, Myfortic, NSC-129185, RS-61443 [AS MOFETIL])
Inosine-5`-monophosphate dehydrogenase in Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /ATCC MYA-565) (Filobasidiella neoformans) [ChEMBL: CHEMBL4295605] [UniProtKB: Q5KP44] There should be some charts here, you may need to enable JavaScript!
inosine monophosphate dehydrogenase 1/Inosine-5`-monophosphate dehydrogenase 1 in Human [ChEMBL: CHEMBL1822] [GtoPdb: 2624] [UniProtKB: P20839] There should be some charts here, you may need to enable JavaScript!
inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Inosine-5`-monophosphate dehydrogenase in Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /ATCC MYA-565) (Filobasidiella neoformans) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295605] [UniProtKB: Q5KP44]
ChEMBL	Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754]
inosine monophosphate dehydrogenase 1/Inosine-5`-monophosphate dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1822] [GtoPdb: 2624] [UniProtKB: P20839]
ChEMBL	Inhibition of human IMPDH 1	B	7.4	pKi	40	nM	Ki	J Med Chem (2007) 50: 6685-6691 [PMID:18038969]
ChEMBL	Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I)	B	7.4	pKi	40	nM	Ki	J Med Chem (2002) 45: 703-712 [PMID:11806722]
ChEMBL	Inhibition of human IMPDH1	B	7.4	pKi	40	nM	Ki	Bioorg Med Chem (2008) 16: 9340-9345 [PMID:18809333]
ChEMBL	Inhibition of human IMP dehydrogenase 1	B	7.4	pKi	40	nM	Ki	Bioorg Med Chem (2008) 16: 7462-7469 [PMID:18583139]
ChEMBL	Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I isoform); Range is 33-37 nM	B	7.48	pKi	33	nM	Ki	J Med Chem (1998) 41: 618-622 [PMID:9484510]
ChEMBL	Inhibition of human IMPDH type 1	B	7.48	pKi	33	nM	Ki	J Med Chem (2007) 50: 5743-5751 [PMID:17958343]
ChEMBL	Inhibition of human IMPDH1 by Spectrophotometry	B	7.48	pKi	33	nM	Ki	Bioorg Med Chem (2011) 19: 1594-1605 [PMID:21324702]
ChEMBL	Inhibition of recombinant human His-tagged IMPDH1 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD	B	6.59	pIC50	260	nM	IC50	Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754]
ChEMBL	Inhibitory activity against inosine monophosphate dehydrogenase IMPDH type I	B	7.26	pIC50	55	nM	IC50	Bioorg Med Chem Lett (2003) 13: 543-546 [PMID:12565968]
ChEMBL	Inhibition of human IMPDH1	B	7.49	pIC50	32	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3479-3483 [PMID:16621550]
ChEMBL	In vitro inhibition of inosine Inosine-5'-monophosphate dehydrogenase	B	7.7	pIC50	20	nM	IC50	J Med Chem (1990) 33: 833-838 [PMID:1967654]
GtoPdb	Reference does not distinguish which enzyme isoform is assayed	-	7.7	pIC50	20	nM	IC50	J Med Chem (1990) 33: 833-8 [PMID:1967654]
ChEMBL	Inhibition of human IMPDH1 expressed in Escherichia coli strain BL21(DE3) after 60 mins	B	7.72	pIC50	19	nM	IC50	Bioorg Med Chem (2010) 18: 8106-8111 [PMID:20934342]
inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268]
ChEMBL	Inhibition of human IMPDH 2	B	8	pKi	10	nM	Ki	J Med Chem (2007) 50: 6685-6691 [PMID:18038969]
ChEMBL	Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II)	B	8	pKi	10	nM	Ki	J Med Chem (2002) 45: 703-712 [PMID:11806722]
ChEMBL	Inhibition of human IMPDH2	B	8	pKi	10	nM	Ki	Bioorg Med Chem (2008) 16: 9340-9345 [PMID:18809333]
ChEMBL	Inhibition of human IMP dehydrogenase 2	B	8	pKi	10	nM	Ki	Bioorg Med Chem (2008) 16: 7462-7469 [PMID:18583139]
ChEMBL	Inhibition of human IMPDH type 2	B	8.15	pKi	7	nM	Ki	J Med Chem (2007) 50: 5743-5751 [PMID:17958343]
ChEMBL	Inhibition of human IMPDH2 by Spectrophotometer	B	8.15	pKi	7	nM	Ki	Bioorg Med Chem (2011) 19: 1594-1605 [PMID:21324702]
ChEMBL	Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II isoform); Range is 6-10 nM	B	8.22	pKi	6	nM	Ki	J Med Chem (1998) 41: 618-622 [PMID:9484510]
ChEMBL	Inhibition of IMPDH2	B	5.82	pIC50	1500	nM	IC50	Bioorg Med Chem Lett (2012) 22: 53-56 [PMID:22172700]
ChEMBL	Inhibition of IMPDH2 using inosine 5'-monophosphate as substrate by spectrophotometry	B	6.2	pIC50	630	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3332-3335 [PMID:22464133]
ChEMBL	Inhibition of human IMPDH2 using IMP as substrate in presence of NAD+ after 30 mins	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2018) 158: 286-301 [PMID:30223117]
ChEMBL	Inhibition of recombinant human His-tagged IMPDH2 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754]
ChEMBL	Compound was tested for inhibition of human recombinant type II Inosine Monophosphate Dehydrogenase at pH 7.4	B	7.6	pIC50	25.1	nM	IC50	J Med Chem (1996) 39: 4181-4196 [PMID:8863796]
ChEMBL	Compound was tested for inhibition of human recombinant type II Inosine Monophosphate Dehydrogenase at pH 8.0	B	7.61	pIC50	24.8	nM	IC50	J Med Chem (1996) 39: 4181-4196 [PMID:8863796]
GtoPdb	Reference does not distinguish which enzyme isoform is assayed	-	7.7	pIC50	20	nM	IC50	J Med Chem (1990) 33: 833-8 [PMID:1967654]
ChEMBL	Inhibition of human IMPDH2	B	7.8	pIC50	16	nM	IC50	J Med Chem (2007) 50: 3730-3742 [PMID:17585753]
ChEMBL	In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2.	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2931-2934 [PMID:12270177]
ChEMBL	Inhibition of Inosine Monophosphate Dehydrogenase II (IMPDH II)	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2002) 12: 3125-3128 [PMID:12372516]
ChEMBL	Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3557-3560 [PMID:14505670]
ChEMBL	Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determined	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2002) 12: 3305-3308 [PMID:12392738]
ChEMBL	Inhibition of human Inosine-5'-monophosphate dehydrogenase 2	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2137-2140 [PMID:12127522]
ChEMBL	Inhibition of human inosine monophosphate dehydrogenase IMPDH II	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2003) 13: 543-546 [PMID:12565968]
ChEMBL	Inhibitory activity against inosine monophosphate dehydrogenase IMPDH II	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2003) 13: 547-551 [PMID:12565969]
ChEMBL	Inhibition of human inosine-5'-monophosphate dehydrogenase 2	B	7.85	pIC50	14	nM	IC50	J Med Chem (2002) 45: 2127-2130 [PMID:12014950]
ChEMBL	Inhibition of human IMPDH2 expressed in Escherichia coli strain BL21(DE3) after 60 mins	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem (2010) 18: 8106-8111 [PMID:20934342]
ChEMBL	Inhibition of human IMPDH2	B	7.96	pIC50	11	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3479-3483 [PMID:16621550]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells	F	6	pIC50	1000	nM	IC50	Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection	F	5.3	pIC50	>5000	nM	IC50	Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]