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ChEMBL ligand: CHEMBL11 (Antideprin, Berkomine, Cristalia, Imipramine, Janimine, Melipramine, NSC-169866, ORG-2463, Pramine, Presamine, Sermonil, Tofranil, Tofranil-PM, Trimipramine maleate impurity, imipramine-) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] | ||||||||
ChEMBL | Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (1990) 33: 2899-2905 [PMID:1976813] |
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Binding affinity towards dopamine receptor D2 using [3H]spiperone as radioligand | B | 6.14 | pKi | 726 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2279-2283 [PMID:15081025] |
ChEMBL | Binding affinity to dopamine D2 receptor (unknown origin) by radioligand binding assay | B | 6.39 | pIC50 | 410 | nM | IC50 | J Med Chem (2013) 56: 8955-8971 [PMID:23919353] |
D2 receptor/Dopamine D2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3427] [GtoPdb: 215] [UniProtKB: P61168] | ||||||||
ChEMBL | Binding affinity to Dopamine receptor D2 using [3H]spiperone as radioligand in stably transfected NIH3T3 cells | B | 6.14 | pKi | 726 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 655-658 [PMID:11266163] |
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
ChEMBL | Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells | B | 4.59 | pIC50 | 25600 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138] |
DAT/Dopamine transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2799] [GtoPdb: 927] [UniProtKB: Q61327] | ||||||||
ChEMBL | Tested in vitro for dopamine(DA) neuronal uptake inhibition | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1990) 33: 2793-2797 [PMID:2213832] |
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] | ||||||||
ChEMBL | Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomes | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1987) 30: 1433-1454 [PMID:3039136] |
ChEMBL | Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamine | F | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (1984) 27: 1508-1515 [PMID:6492080] |
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
ChEMBL | Inhibition of [3H]MK-801 binding to NMDA receptor of rat cerebral cortical synaptic membrane | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (1995) 38: 2964-2968 [PMID:7636857] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1 | F | 5.47 | pIC50 | 3400 | nM | IC50 | J Med Chem (2002) 45: 3844-3853 [PMID:12190308] |
ChEMBL | Inhibition of hERG K channel | F | 5.47 | pIC50 | 3400 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
ChEMBL | Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) | F | 5.47 | pIC50 | 3388.44 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1737-1741 [PMID:15745831] |
ChEMBL | Inhibitory concentration against potassium channel HERG | B | 5.47 | pIC50 | 3388.44 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273] |
ChEMBL | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique | B | 5.47 | pIC50 | 3388.44 | nM | IC50 | Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342] |
ChEMBL | Inhibition of human ERG in MCF7 cells | B | 5.47 | pIC50 | 3388.44 | nM | IC50 | Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341] |
ChEMBL | Inhibition of human ERG | B | 5.47 | pIC50 | 3388.44 | nM | IC50 | Eur J Med Chem (2011) 46: 618-630 [PMID:21185626] |
ChEMBL | Inhibition of human Potassium channel HERG expressed in mammalian cells | B | 5.47 | pIC50 | 3388.44 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512] |
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] | ||||||||
ChEMBL | Binding affinity to H1 receptor (unknown origin) | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127493-127493 [PMID:32798652] |
ChEMBL | Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (2013) 56: 8955-8971 [PMID:23919353] |
H1 receptor/Histamine H1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4701] [GtoPdb: 262] [UniProtKB: P31390] | ||||||||
ChEMBL | Compound tested for its inhibitory activity against Histamine H1 receptor | B | 10.22 | pIC50 | 0.06 | nM | IC50 | J Med Chem (1999) 42: 3154-3162 [PMID:10447960] |
Histamine H2 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2882] [UniProtKB: P47747] | ||||||||
ChEMBL | Inhibitory activity against brain adenylate cyclase Histamine H2 receptor | F | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (1999) 42: 3154-3162 [PMID:10447960] |
M5 receptor/Muscarinic acetylcholine receptor M5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL277] [GtoPdb: 17] [UniProtKB: P08911] | ||||||||
ChEMBL | Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1984) 27: 995-1003 [PMID:6747997] |
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
ChEMBL | Binding affinity towards Norepinephrine transporter using [3H]nisoxitine as radioligand | B | 7.8 | pKi | 16 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2279-2283 [PMID:15081025] |
GtoPdb | - | - | 7.8 | pKi | 16 | nM | Ki | |
ChEMBL | Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells | B | 7.13 | pIC50 | 74 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138] |
NET/Norepinephrine transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2370] [GtoPdb: 926] [UniProtKB: O55192] | ||||||||
ChEMBL | Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cells | B | 7.8 | pKi | 16 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 655-658 [PMID:11266163] |
ChEMBL | Tested in vitro for norepinephrine (NE) neuronal uptake inhibition | B | 7.92 | pKi | 12 | nM | Ki | J Med Chem (1990) 33: 2793-2797 [PMID:2213832] |
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4] | ||||||||
ChEMBL | Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomes | B | 7.92 | pKi | 12 | nM | Ki | J Med Chem (1987) 30: 1433-1454 [PMID:3039136] |
ChEMBL | In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slices | F | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1981) 24: 1499-1507 [PMID:6458703] |
ChEMBL | Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes | F | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (1990) 33: 2899-2905 [PMID:1976813] |
ChEMBL | Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrine | F | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (1984) 27: 1508-1515 [PMID:6492080] |
Pleiotropic ABC efflux transporter of multiple drugs in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697658] [UniProtKB: P33302] | ||||||||
ChEMBL | Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay | B | 4.66 | pIC50 | 22000 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1516-1527 [PMID:19188399] |
Prion protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4869] [UniProtKB: P04156] | ||||||||
ChEMBL | Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells | B | 5 | pEC50 | 10000 | nM | EC50 | J Med Chem (2003) 46: 3563-3564 [PMID:12904059] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
ChEMBL | Displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor expressed NIH3T3 cells | B | 6.8 | pKi | 160 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 655-658 [PMID:11266163] |
ChEMBL | Binding affinity towards 5-hydroxytryptamine 2A receptor using [3H]ketanserin | B | 7.03 | pKi | 94 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2279-2283 [PMID:15081025] |
ChEMBL | Binding affinity to 5HT2A receptor (unknown origin) by radioligand binding assay | B | 6.66 | pIC50 | 220 | nM | IC50 | J Med Chem (2013) 56: 8955-8971 [PMID:23919353] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | Binding affinity towards 5-hydroxytryptamine 2C receptor using [3H]mesulergine as radioligand | B | 6.8 | pKi | 160 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2279-2283 [PMID:15081025] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3006] [GtoPdb: 8] [UniProtKB: P34968] | ||||||||
ChEMBL | Binding affinity to 5-hydroxytryptamine 2C receptor using [3H]Mesulergine as radioligand in stably transfected NIH3T3 cells | B | 6.8 | pKi | 160 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 655-658 [PMID:11266163] |
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
ChEMBL | Inhibition of human SERT I172M mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5HT and compound for 10 mins by micro-scintillation counter | B | 5.89 | pKi | 1300 | nM | Ki | Bioorg Med Chem (2016) 24: 2725-2738 [PMID:27160055] |
ChEMBL | Inhibition of wild-type human SERT expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5HT and compound for 10 mins by micro-scintillation counter | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2016) 24: 2725-2738 [PMID:27160055] |
GtoPdb | Displacement of [3H]citalopram from hSERT. | - | 7.69 | pKi | 20.3 | nM | Ki | J Nat Prod (1993) 56: 441-55 [PMID:8496700] |
ChEMBL | Displacement of [3H]citalopram from serotonin transporter | B | 7.69 | pKi | 20.3 | nM | Ki | J Nat Prod (1993) 56: 441-455 [PMID:8496700] |
ChEMBL | Binding affinity to SERT (unknown origin) | B | 7.7 | pKi | 20 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127493-127493 [PMID:32798652] |
ChEMBL | Inhibition of [3H]serotonin reuptake at serotonin transporter | B | 8.12 | pKi | 7.57 | nM | Ki | J Med Chem (2009) 52: 5872-5879 [PMID:19791802] |
ChEMBL | Inhibition of human SERT I179C mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5HT and compound for 10 mins by micro-scintillation counter | B | 8.24 | pKi | 5.7 | nM | Ki | Bioorg Med Chem (2016) 24: 2725-2738 [PMID:27160055] |
ChEMBL | Binding affinity towards Serotonin transporter using [3H]paroxetine as radioligand | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2279-2283 [PMID:15081025] |
ChEMBL | Displacement of radiolabeled imipramine from human SERT | B | 8.49 | pKi | 3.2 | nM | Ki | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
ChEMBL | Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK293 cells membranes incubated for 30 mins by microbeta scintillation counting analysis | B | 8.6 | pKi | 2.5 | nM | Ki | Eur J Med Chem (2019) 183: 111736-111736 [PMID:31586817] |
ChEMBL | Displacement of [3H]imipramine from human recombinant SERT expressed in CHO cells | B | 8.68 | pKi | 2.1 | nM | Ki | J Med Chem (2014) 57: 4543-4557 [PMID:24805037] |
ChEMBL | Displacement of [3H]imipramine from human SERT expressed in CHO cells | B | 8.68 | pKi | 2.1 | nM | Ki | Eur J Med Chem (2015) 92: 221-235 [PMID:25557493] |
ChEMBL | Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting method | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem (2017) 25: 293-304 [PMID:27865645] |
ChEMBL | Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter method | B | 8.72 | pKi | 1.9 | nM | Ki | Eur J Med Chem (2019) 176: 292-309 [PMID:31112891] |
ChEMBL | Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK-293 cell membranes after 30 mins by scintillation counting | B | 9 | pKi | 1 | nM | Ki | J Med Chem (2017) 60: 7483-7501 [PMID:28763213] |
ChEMBL | Displacement of [3H]imipramine from human 5HT transporter | B | 9.11 | pKi | 0.77 | nM | Ki | J Med Chem (2011) 54: 5320-5334 [PMID:21726069] |
ChEMBL | Binding affinity to human 5-HT transporter by radioligand displacement assay | B | 9.28 | pKi | 0.52 | nM | Ki | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
ChEMBL | Inhibition of SERT (unknown origin) | B | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
ChEMBL | Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assay | B | 7.54 | pIC50 | 29 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1220-1224 [PMID:23385211] |
ChEMBL | Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cells | B | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138] |
ChEMBL | Inhibition of human 5-HT transporter | B | 8.14 | pIC50 | 7.3 | nM | IC50 | Bioorg Med Chem (2010) 18: 7675-7699 [PMID:20875743] |
ChEMBL | Displacement of radiolabeled imipramine from human SERT | B | 8.16 | pIC50 | 6.9 | nM | IC50 | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
ChEMBL | Displacement of [3H]imipramin from human recombinant SERT over-expressed in HEK293 cells | B | 8.17 | pIC50 | 6.8 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5515-5518 [PMID:24012181] |
ChEMBL | Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serotonin addition measured after 20 mins by liquid scintillation counting method | B | 8.29 | pIC50 | 5.1 | nM | IC50 | Bioorg Med Chem (2017) 25: 293-304 [PMID:27865645] |
ChEMBL | Percent inhibition against 5-hydroxytryptamine transporter at 1 uM nonselective | B | 8.36 | pIC50 | 4.4 | nM | IC50 | J Med Chem (2005) 48: 6887-6896 [PMID:16250647] |
ChEMBL | Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter method | B | 8.39 | pIC50 | 4.1 | nM | IC50 | Eur J Med Chem (2019) 176: 292-309 [PMID:31112891] |
ChEMBL | Binding affinity to SERT (unknown origin) by radioligand binding assay | B | 8.46 | pIC50 | 3.5 | nM | IC50 | J Med Chem (2013) 56: 8955-8971 [PMID:23919353] |
ChEMBL | Inhibition of human SERT W103A mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5HT and compound for 10 mins by micro-scintillation counter | B | 8.59 | pIC50 | 2.6 | nM | IC50 | Bioorg Med Chem (2016) 24: 2725-2738 [PMID:27160055] |
ChEMBL | Binding affinity to human serotonin 5-HT transporter by radioligand displacement assay | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449] |
ChEMBL | Binding affinity to human 5-HT transporter by radioligand displacement assay | B | 8.96 | pIC50 | 1.1 | nM | IC50 | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
ChEMBL | Displacement of [3H]imipramine from human recombinant 5HT transporter expressed in CHO cells measured after 60 mins by scintillation counting method | B | 9.06 | pIC50 | 0.88 | nM | IC50 | Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250] |
ChEMBL | Displacement of [3H]imipramine from human recombinant 5-HT transporter expressed in CHO cells | B | 9.06 | pIC50 | 0.88 | nM | IC50 | Bioorg Med Chem (2016) 24: 1793-1810 [PMID:26988801] |
SERT/Serotonin transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4642] [GtoPdb: 928] [UniProtKB: Q60857] | ||||||||
ChEMBL | Tested in vitro for serotonin(5-HT) neuronal uptake inhibition | B | 7.38 | pKi | 42 | nM | Ki | J Med Chem (1990) 33: 2793-2797 [PMID:2213832] |
ChEMBL | Binding affinity to Serotonin transporter using [3H]-paroxetine as radioligand in stably transfected NIH3T3 cells | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 655-658 [PMID:11266163] |
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
ChEMBL | Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomes | B | 7.38 | pKi | 41.8 | nM | Ki | J Med Chem (1987) 30: 1433-1454 [PMID:3039136] |
ChEMBL | Displacement of [3H]-citalopram from SERT in rat cortex tissue incubated for 60 mins by microbeta scintillation counting method | B | 7.54 | pKi | 29 | nM | Ki | Eur J Med Chem (2019) 180: 383-397 [PMID:31325785] |
ChEMBL | Displacement of [3H]-citalopram from SERT in rat cortex tissue measured after 60 mins by microbeta scintillation counting analysis | B | 7.54 | pKi | 29 | nM | Ki | Eur J Med Chem (2019) 166: 144-158 [PMID:30703658] |
ChEMBL | Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HT | F | 6.09 | pIC50 | 810 | nM | IC50 | J Med Chem (1984) 27: 1508-1515 [PMID:6492080] |
ChEMBL | In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slices | F | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1981) 24: 1499-1507 [PMID:6458703] |
ChEMBL | Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes | F | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (1990) 33: 2899-2905 [PMID:1976813] |
ChEMBL | Inhibition of SERT expressed in rat brain synaptosomes assessed as decrease in incorporation of [3H]serotonin measured after 15 mins by scintillation counting method | B | 7.21 | pIC50 | 61 | nM | IC50 | J Med Chem (2017) 60: 7483-7501 [PMID:28763213] |
σ2/Sigma intracellular receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7] | ||||||||
ChEMBL | Displacement of [3H]DTG from sigma 2 receptor in Sprague-Dawley rat brain membranes in presence of (+)-pentazocine by scintillation counting method | B | 5.68 | pKi | 2107 | nM | Ki | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] | ||||||||
ChEMBL | Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting method | B | 6.46 | pKi | 343 | nM | Ki | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 4.77 | pIC50 | 17100 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
ChEMBL | Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay | B | 5.1 | pIC50 | 7950 | nM | IC50 | J Med Chem (2017) 60: 2685-2696 [PMID:28230985] |
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT1-expressing MDCK cells | F | 4.8 | pIC50 | 16000 | nM | IC50 | Pharm Res (2001) 18: 1528-1534 [PMID:11758759] |
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT2-expressing MDCK cells | F | 5 | pIC50 | 9900 | nM | IC50 | Pharm Res (2001) 18: 1528-1534 [PMID:11758759] |
Organic cation transporter 3/Solute carrier family 22 member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073673] [GtoPdb: 1021] [UniProtKB: O75751] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of MPP+ uptake in OCT3-expressing HRPE cells | F | 4.38 | pKi | 42000 | nM | Ki | Am J Physiol Renal Physiol (2000) 279: F449-F458 [PMID:10966924] |
sphingomyelin phosphodiesterase 1/Sphingomyelin phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2760] [GtoPdb: 2514] [UniProtKB: P17405] | ||||||||
ChEMBL | Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates using 3H-sphingomyelin as substrate preincubated for 30 mins followed by mmLDL stimulation measured after 2 hrs by HPLC method | B | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2018) 153: 73-104 [PMID:29031494] |
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes | F | 5.08 | pIC50 | 8300 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes | F | 5.39 | pIC50 | 4050 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975] | ||||||||
ChEMBL | Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging assay | B | 4.66 | pIC50 | 22000 | nM | IC50 | RSC Med Chem (2022) 13: 183-195 [PMID:35308021] |
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
GtoPdb | - | - | 6.9 | pKi | - | - | - | J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790] |
Kir3.2 in Mouse [GtoPdb: 435] [UniProtKB: P48542] | ||||||||
GtoPdb | - | - | 4.3 | pIC50 | - | - | - | Neuropsychopharmacology (2004) 29: 1841-51 [PMID:15150531] |
Kir3.4 in Mouse [GtoPdb: 437] [UniProtKB: P48545] | ||||||||
GtoPdb | - | - | 4.5 | pEC50 | - | - | - | Neuropsychopharmacology (2004) 29: 1841-51 [PMID:15150531] |
Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259] | ||||||||
GtoPdb | - | - | 5.7 | pIC50 | - | - | - | J Gen Physiol (2004) 124: 301-17 [PMID:15365094] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]