isoniazid [Ligand Id: 12761] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL64 (Armazid, Armazide, Atcotibine, Cedin, Cotinazin, Dianicotyl, Dow-isoniazid, Eralon, Ertuban, Hidrasonil, Hydrazid, Hyzyd, Ipcazide, Iscotin, Isidrina, Isobicina, Isoniazid, Isoniazida, Isoniazide, Isoniazidum, Isonicotan, Isonicotinylhydrazine, Laniazid, Mybasan, Neumandin, Nicotibine, NSC-9659, Nydrazid, Rimifon, Stanozide, Teebaconin, Tisiodrazida) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dihydrofolate reductase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6065] [UniProtKB: P9WNX1] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis dihydrofolate reductase | B | 9 | pKi | 1 | nM | Ki | Antimicrob Agents Chemother (2010) 54: 3776-3782 [PMID:20566771] |
| DNA gyrase subunit A/DNA gyrase subunit B in Mycobacterium tuberculosis (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430898] [UniProtKB: P9WG45, P9WG47] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by electrophoresis | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2016) 24: 877-885 [PMID:26787274] |
| Endonuclease 8-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523426] [UniProtKB: Q96FI4] | ||||||||
| ChEMBL | Inhibition of NEIL1 (unknown origin) using Sp/Gh substrate incubated for 40 mins by TAMRA fluorescence-based assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | US-20170038365-A1. Small molecule inhibitors of 8-oxoguanine dna glycosylase-1 (ogg1) (2017) |
| Endonuclease III-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523264] [UniProtKB: P78549] | ||||||||
| ChEMBL | Inhibition of NTH1 (unknown origin) incubated for 40 mins by TAMRA fluorescence-based assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | US-20170038365-A1. Small molecule inhibitors of 8-oxoguanine dna glycosylase-1 (ogg1) (2017) |
| Enoyl-[acyl-carrier-protein] reductase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1849] [UniProtKB: P9WGR1] | ||||||||
| ChEMBL | Binding affinity to Mycobacterium tuberculosis H37Rv InhA assessed as dissociation constant in presence of NADH, octenoyl-CoA and KatG | B | 9.4 | pKd | <0.4 | nM | Kd | Eur J Med Chem (2023) 245: 114908-114908 [PMID:36435016] |
| ChEMBL | Binding affinity to wild type Mycobacterium tuberculosis InhA assessed as inhibition constant for formation of enzyme-inhibitor complex in presence of NADH and DD-CoA by spectrophotometry based analysis | B | 7.8 | pKi | 16 | nM | Ki | Eur J Med Chem (2023) 245: 114908-114908 [PMID:36435016] |
| ChEMBL | Binding affinity to wild type Mycobacterium tuberculosis InhA assessed as inhibition constant in presence of NADH, DD-CoA by spectrophotometry based analysis | B | 9.12 | pKi | 0.75 | nM | Ki | Eur J Med Chem (2023) 245: 114908-114908 [PMID:36435016] |
| ChEMBL | Inhibition of recombinant Mycobacterium tuberculosis InhA expressed in Escherichia coli Rosette(DE3) pLysS using trans-2-decenoyl-N-acetylcysteamine as substrate by spectrophotometric method | B | 5.08 | pIC50 | 8290 | nM | IC50 | Bioorg Med Chem (2019) 27: 1509-1516 [PMID:30846404] |
| Formamidopyrimidine-DNA glycosylase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523167] [UniProtKB: P05523] | ||||||||
| ChEMBL | Inhibition of Escherichia coli FPG using 8-oxo-Gua substrate incubated for 10 mins by TAMRA fluorescence-based assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | US-20170038365-A1. Small molecule inhibitors of 8-oxoguanine dna glycosylase-1 (ogg1) (2017) |
| myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] | ||||||||
| ChEMBL | Irreversible inhibition of MPO (unknown origin) | B | 5.3 | pIC50 | 5000 | nM | IC50 | ACS Med Chem Lett (2017) 8: 206-210 [PMID:28197313] |
| ChEMBL | Inhibition of human MPO | B | 5.33 | pIC50 | 4700 | nM | IC50 | ACS Med Chem Lett (2017) 8: 206-210 [PMID:28197313] |
| 8-oxoguanine DNA glycosylase/N-glycosylase/DNA lyase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3396944] [GtoPdb: 3060] [UniProtKB: O15527] | ||||||||
| ChEMBL | Inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by PAGE-based cleavage assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | US-20170038365-A1. Small molecule inhibitors of 8-oxoguanine dna glycosylase-1 (ogg1) (2017) |
| ChEMBL | Inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by TAMRA fluorescence-based assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | US-20170038365-A1. Small molecule inhibitors of 8-oxoguanine dna glycosylase-1 (ogg1) (2017) |
| Pantothenate synthetase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6069] [UniProtKB: P9WIL5] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem (2014) 22: 1938-1947 [PMID:24565972] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) by spectrophotometry | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem (2014) 22: 4223-4232 [PMID:24953948] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ formation by spectrophotmetry in presence of NADH | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem (2016) 24: 1298-1307 [PMID:26867485] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | DNDI: Malaria in Vitro, 72 hour | F | 4.44 | pIC50 | >36460 | nM | IC50 | Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
