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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 345 | 3p25.3 | OGG1 | 8-oxoguanine DNA glycosylase | |
| Mouse | - | 345 | 6 52.75 cM | Ogg1 | 8-oxoguanine DNA-glycosylase 1 | |
| Rat | - | 345 | 4q42 | Ogg1 | 8-oxoguanine DNA glycosylase | |
| Gene and Protein Information Comments | ||||||
| Many alternative splice variants for the human gene have been described. The predominant human transcript is variant 1a that gives rise to protein isoform 1a (345 amino acids). | ||||||
| Previous and Unofficial Names |
| 8-hydroxyguanine DNA glycosylase | HMMH | MUTM | OGH1 |
| Database Links |
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| Alphafold | O15527 (Hs), O08760 (Mm), O70249 (Rn) |
| ChEMBL Target | CHEMBL3396944 (Hs) |
| Ensembl Gene | ENSG00000114026 (Hs), ENSMUSG00000030271 (Mm), ENSRNOG00000052140 (Rn) |
| Entrez Gene | 4968 (Hs), 18294 (Mm), 81528 (Rn) |
| Human Protein Atlas | ENSG00000114026 (Hs) |
| KEGG Gene | hsa:4968 (Hs), mmu:18294 (Mm), rno:81528 (Rn) |
| OMIM | 601982 (Hs) |
| Pharos | O15527 (Hs) |
| RefSeq Nucleotide | NM_002542 (Hs), NM_010957 (Mm), NM_030870 (Rn) |
| RefSeq Protein | NP_00253 (Hs), NP_035087 (Mm), NP_110497 (Rn) |
| UniProtKB | O15527 (Hs), O08760 (Mm), O70249 (Rn) |
| Wikipedia | OGG1 (Hs) |
Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| OGG1 has recognised roles in processes that are associated with innate and adaptive immunity [1-2], particulary as an initiator of proinflammtory responses [1]. At least some of OGG1's actions in the immune system and inflammation are related to its ability to recruit site-specific transcription factors and modulate the expression of genes that are involved in the producation of chemokines/cytokines and the activation/recruitment of inflammatory cells, in order to mount an effective innate immune response. As a result, pharmacological OGG1 inhibition is being explored as a novel antiinflammatory mechanism. |
| Immuno Process Associations | ||
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| Physiological Consequences of Altering Gene Expression
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| General Comments |
| The OGG1 enzyme is responsible for the excision of 8-oxoguanine from oxidatively-damaged DNA. It is located intracellularly to mitochondria. OGG1 has also been identified as a transcription modulator, that can regulate transcription factor homing, recruit chromatin remodelers and induce downstream signaling cascades that alter gene expression. |
1. Aguilera-Aguirre L, Bacsi A, Radak Z, Hazra TK, Mitra S, Sur S, Brasier AR, Ba X, Boldogh I. (2014) Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway. J Immunol, 193 (9): 4643-53. [PMID:25267977]
2. Ba X, Bacsi A, Luo J, Aguilera-Aguirre L, Zeng X, Radak Z, Brasier AR, Boldogh I. (2014) 8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. J Immunol, 192 (5): 2384-94. [PMID:24489103]
3. Bacsi A, Aguilera-Aguirre L, Szczesny B, Radak Z, Hazra TK, Sur S, Ba X, Boldogh I. (2013) Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation. DNA Repair (Amst.), 12 (1): 18-26. [PMID:23127499]
4. Li G, Yuan K, Yan C, Fox 3rd J, Gaid M, Breitwieser W, Bansal AK, Zeng H, Gao H, Wu M. (2012) 8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice. Free Radic Biol Med, 52 (2): 392-401. [PMID:22100973]
5. Touati E, Michel V, Thiberge JM, Avé P, Huerre M, Bourgade F, Klungland A, Labigne A. (2006) Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse. Helicobacter, 11 (5): 494-505. [PMID:16961812]
6. Visnes T, Cázares-Körner A, Hao W, Wallner O, Masuyer G, Loseva O, Mortusewicz O, Wiita E, Sarno A, Manoilov A et al.. (2018) Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science, 362 (6416): 834-839. [PMID:30442810]
DNA glycosylases: 8-oxoguanine DNA glycosylase. Last modified on 16/01/2019. Accessed on 19/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3060.
target has curated data in GtoImmuPdb
