[3H]NGD941 [Ligand Id: 3297] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL103772 ([3H]NGD-941) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity on human Dopamine receptor D2 expressed in CHO cells using radioligand [3H]-YM 09151 | B | 5.65 | pKi | 2250 | nM | Ki | J Med Chem (1997) 40: 1-3 [PMID:9016321] |
| ChEMBL | Inhibition of human dopamine D2 receptor | B | 5.65 | pKi | 2230 | nM | Ki | J Med Chem (2017) 60: 7233-7243 [PMID:28489950] |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Binding affinity on human Dopamine receptor D3 expressed in CHO cells using radioligand [3H]-YM 09151 | B | 5.1 | pKi | >8000 | nM | Ki | J Med Chem (1997) 40: 1-3 [PMID:9016321] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| GtoPdb | - | - | 8.3 | pKd | 5 | nM | Kd | J Pharmacol Exp Ther (1997) 282: 1020-7 [PMID:9262371] |
| ChEMBL | Binding affinity on human Dopamine receptor D4 expressed in CHO cells using radioligand [3H]-YM 09151 | B | 8.42 | pKi | 3.8 | nM | Ki | J Med Chem (1997) 40: 1-3 [PMID:9016321] |
| ChEMBL | Binding affinity towards human dopamine receptor D4 | B | 8.44 | pKi | 3.6 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1A receptor | B | 6.74 | pKi | 181 | nM | Ki | J Med Chem (1997) 40: 1-3 [PMID:9016321] |
| ChEMBL | Inhibition of serotonin 5-HT1A receptor (unknown origin) | B | 6.74 | pKi | 180 | nM | Ki | J Med Chem (2017) 60: 7233-7243 [PMID:28489950] |
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Inhibition of serotonin 5-HT3 receptor (unknown origin) | B | 6.12 | pKi | 750 | nM | Ki | J Med Chem (2017) 60: 7233-7243 [PMID:28489950] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
