compound 31 [PMID: 24809814] [Ligand Id: 8465] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3290331
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  • sphingosine-1-phosphate lyase 1/Sphingosine-1-phosphate lyase 1 in Human [ChEMBL: CHEMBL3286061] [GtoPdb: 2522] [UniProtKB: O95470]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
SMO/Smoothened homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5971] [GtoPdb: 239] [UniProtKB: Q99835]
ChEMBL Antagonist activity at smoothened (unknown origin) B 6.36 pIC50 440 nM IC50 J Med Chem (2014) 57: 5074-5084 [PMID:24809814]
sphingosine-1-phosphate lyase 1/Sphingosine-1-phosphate lyase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286061] [GtoPdb: 2522] [UniProtKB: O95470]
ChEMBL Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr B 6.68 pIC50 210 nM IC50 J Med Chem (2014) 57: 5074-5084 [PMID:24809814]
GtoPdb - - 6.68 pIC50 210 nM IC50 J Med Chem (2014) 57: 5074-84 [PMID:24809814];
Biochem Biophys Res Commun (2013) 433: 345-8 [PMID:23499842];
J Pharmacol Exp Ther (2016) 359: 151-8 [PMID:27519818];
Toxicol Pathol (2015) 43: 694-703 [PMID:25630683]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]