doxorubicin [Ligand Id: 7069] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL53463 (NSC-123127, Doxorubicin, Rubex, Hydroxydaunorubicin, Adriblastina, Adriamycin, Doxil, Valrubicin impurity, doxorubicin)
There should be some charts here, you may need to enable JavaScript!
  • Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
There should be some charts here, you may need to enable JavaScript!
  • Carnitine palmitoyltransferase 2 in Rat [ChEMBL: CHEMBL4037] [UniProtKB: P18886]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • CDGSH iron-sulfur domain-containing protein 1 in Human [ChEMBL: CHEMBL1795168] [UniProtKB: Q9NZ45]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
There should be some charts here, you may need to enable JavaScript!
  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
There should be some charts here, you may need to enable JavaScript!
  • ABCC1/Multidrug resistance-associated protein 1 in Human [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
There should be some charts here, you may need to enable JavaScript!
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • P2Y12 receptor/Purinergic receptor P2Y12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
There should be some charts here, you may need to enable JavaScript!
  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
There should be some charts here, you may need to enable JavaScript!
  • Reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL2366516] [UniProtKB: Q9WKE8]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
There should be some charts here, you may need to enable JavaScript!
  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
There should be some charts here, you may need to enable JavaScript!
  • Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
There should be some charts here, you may need to enable JavaScript!
  • Telomerase reverse transcriptase in Human [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
There should be some charts here, you may need to enable JavaScript!
  • Type-2 restriction enzyme HindIII in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [ChEMBL: CHEMBL5004] [UniProtKB: P43870]
There should be some charts here, you may need to enable JavaScript!
  • Type-2 restriction enzyme ScaI in Streptomyces caespitosus [ChEMBL: CHEMBL5782] [UniProtKB: O52691]
There should be some charts here, you may need to enable JavaScript!
  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
There should be some charts here, you may need to enable JavaScript!
  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Anti-estrogen binding site (AEBS) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL612409] [UniProtKB: Q15125Q9UBM7]
ChEMBL Growth inhibition of MDA-MB-231 cells containing antiestrogen binding sites F 6.52 pIC50 300 nM IC50 J. Med. Chem. (2004) 47: 6509-6518 [PMID:15588086]
ChEMBL Growth inhibition of MCF7 cells expressing ER and antiestrogen binding sites F 6.7 pIC50 200 nM IC50 J. Med. Chem. (2004) 47: 6509-6518 [PMID:15588086]
ChEMBL Growth inhibition of MDA-MB-435 cells containing antiestrogen binding sites F 6.82 pIC50 150 nM IC50 J. Med. Chem. (2004) 47: 6509-6518 [PMID:15588086]
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) B 4.87 pIC50 13590 nM IC50 DrugMatrix in vitro pharmacology data
Carnitine palmitoyltransferase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4037] [UniProtKB: P18886]
ChEMBL Inhibition of rat CPT2 in rat mitochondria B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2011) 54: 3109-3152 [PMID:21504156]
Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466]
ChEMBL DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) B 4.91 pIC50 12192 nM IC50 DrugMatrix in vitro pharmacology data
CDGSH iron-sulfur domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795168] [UniProtKB: Q9NZ45]
ChEMBL Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis B 5.46 pKi 3451 nM Ki Bioorg Med Chem Lett (2016) 26: 5350-5353 [PMID:27687671]
ChEMBL Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by scintillation proximity assay B 4.09 pIC50 80760 nM IC50 Bioorg Med Chem Lett (2016) 26: 5350-5353 [PMID:27687671]
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis B 4.7 pIC50 20000 nM IC50 J. Med. Chem. (2010) 53: 6164-6179 [PMID:20662543]
DNA topoisomerase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1806] [GtoPdb: 2637] [UniProtKB: P11388]
ChEMBL Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast DNA after 60 mins by agarose gel electrophoresis B 5.52 pIC50 3000 nM IC50 Eur J Med Chem (2016) 123: 704-717 [PMID:27521587]
ChEMBL Inhibition of human topoisomerase 2alpha-mediated kinetoplast DNA decatenation after 60 mins by ethidium bromide staining based agarose gel electrophoresis B 5.52 pIC50 3000 nM IC50 Bioorg Med Chem (2017) 25: 2625-2634 [PMID:28342691]
GtoPdb In vitro inhibition of DNA relaxation and decatenation activities in a topoisomerase extract from human placenta. - 6 pIC50 1000 nM IC50 J. Nat. Prod. (2001) 64: 204-7 [PMID:11430001]
ChEMBL Inhibition human placenta topoisomerase 2 assessed as conversion of supercoiled pBR322 DNA to relaxed form B 6 pIC50 1000 nM IC50 J. Nat. Prod. (2001) 64: 204-207 [PMID:11430001]
ChEMBL Inhibition human placenta topoisomerase 2 assessed as conversion of catenated kinetoplast DNA to minicircle monomer B 6 pIC50 1000 nM IC50 J. Nat. Prod. (2001) 64: 204-207 [PMID:11430001]
ChEMBL Inhibition of human topoisomerase 2 using supercoiled pHOT1 DNA as substrate after 30 mins by agarose gel electrophoresis B 6.06 pIC50 880 nM IC50 Eur J Med Chem (2018) 155: 117-134 [PMID:29885574]
DNA topoisomerase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3396] [UniProtKB: Q02880]
ChEMBL Inhibition of human topoisomerase-2B after 2 hrs by ELISA B 5.46 pIC50 3500 nM IC50 Eur J Med Chem (2018) 150: 403-418 [PMID:29547830]
ChEMBL Inhibition of human topoisomerase 2beta after 2 hrs at 37 degC by ELISA B 5.46 pIC50 3500 nM IC50 Eur J Med Chem (2018) 143: 1807-1825 [PMID:29133058]
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
ChEMBL Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer B 5.62 pIC50 2400 nM IC50 J. Med. Chem. (2000) 43: 2100-2114 [PMID:10841789]
ChEMBL Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing B 6.05 pIC50 900 nM IC50 J. Med. Chem. (2000) 43: 2100-2114 [PMID:10841789]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibitory concentration against Clostridium histolyticum Collagenase B 5.96 pIC50 1100 nM IC50 J. Med. Chem. (1992) 35: 2768-2771 [PMID:1322986]
ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
ChEMBL TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.05 uM) in membrane vesicle from MRP1-expressing HeLa cells F 4.3 pIC50 50000 nM IC50 J. Biol. Chem. (1996) 271: 9683-9689 [PMID:8621644]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.43 pKi 3693 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 4.81 pIC50 15336 nM IC50 DrugMatrix in vitro pharmacology data
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cells F 5.07 pKi 8500 nM Ki Pharm. Res. (2001) 18: 171-176 [PMID:11405287]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells F 6.05 pIC50 886 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection F 7.24 pIC50 58 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
ChEMBL Displacement of [3H]PSB0413 from human platelet P2Y12 receptor B 5 pKi >10000 nM Ki J. Med. Chem. (2009) 52: 3784-3793 [PMID:19463000]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) B 5.6 pIC50 2485 nM IC50 DrugMatrix in vitro pharmacology data
Reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366516] [UniProtKB: Q9WKE8]
ChEMBL Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assay B 4.28 pIC50 52000 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 4844-4848 [PMID:22695131]
Ribonuclease pancreatic in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6091] [UniProtKB: P61823]
ChEMBL Inhibition of bovine pancreas RNase A assessed as undigested supercoiled pBR322 DNA concentration B 4.6 pIC50 25000 nM IC50 J. Nat. Prod. (2001) 64: 204-207 [PMID:11430001]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Inhibition of GST-tagged Aurora A kinase expressed in insect cells assessed as inhibition of [33P]gamma-ATP incorporation in substrate after 60 mins by scintillation counting B 7.4 pIC50 40 nM IC50 Eur. J. Med. Chem. (2011) 46: 3690-3695 [PMID:21664013]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) B 4.81 pKi 15666 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) B 4.46 pIC50 34464 nM IC50 DrugMatrix in vitro pharmacology data
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) B 5.68 pKi 2078 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) B 4.9 pIC50 12468 nM IC50 DrugMatrix in vitro pharmacology data
Telomerase reverse transcriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
ChEMBL Inhibition of telomerase from human COLO201 cell B 4.14 pIC50 73000 nM IC50 J. Nat. Prod. (2001) 64: 204-207 [PMID:11430001]
Type-2 restriction enzyme HindIII in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5004] [UniProtKB: P43870]
ChEMBL Inhibition of Haemophilus influenzae Hind 3 assessed as undigested supercoiled pBR322 DNA concentration B 4.02 pIC50 96000 nM IC50 J. Nat. Prod. (2001) 64: 204-207 [PMID:11430001]
Type-2 restriction enzyme ScaI in Streptomyces caespitosus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5782] [UniProtKB: O52691]
ChEMBL Inhibition of Streptomyces caespitosus Sca 1 assessed as undigested supercoiled pBR322 DNA concentration B 4.6 pIC50 25000 nM IC50 J. Nat. Prod. (2001) 64: 204-207 [PMID:11430001]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) B 5.29 pIC50 5147 nM IC50 DrugMatrix in vitro pharmacology data
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) B 4.5 pIC50 31913 nM IC50 DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]