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DNA (cytosine-5-)-methyltransferase 3α

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Target not currently curated in GtoImmuPdb

Target id: 2750

Nomenclature: DNA (cytosine-5-)-methyltransferase 3α

Family: 2.1.1.- Methyltransferases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 912 2p23.3 DNMT3A DNA methyltransferase 3 alpha
Mouse - 908 12 A1.1 Dnmt3a DNA methyltransferase 3A
Rat - 908 6q14 Dnmt3a DNA methyltransferase 3 alpha
Gene and Protein Information Comments
Human DNMT3A has a shorter isoform of 723 amino acids.
Previous and Unofficial Names Click here for help
DNA (cytosine-5-)-methyltransferase 3 alpha
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:
Inhibitor Comments
Azacitidine and decitabine are likely to be inhibitors of DNMT1 and DNMT3A. We infer primary target designation from reports of drug action in in vitro and in vivo studies despite the paucity of pharmacological affinity data.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Tatton-Brown-Rahman syndrome; TBRS
Synonyms: Tall stature-intellectual disability-facial dysmorphism syndrome [Orphanet: ORPHA404443]
OMIM: 615879
Orphanet: ORPHA404443

How to cite this page

2.1.1.- Methyltransferases: DNA (cytosine-5-)-methyltransferase 3α. Last modified on 13/08/2015. Accessed on 20/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,