[Ala11,22,28]VIP [Ligand Id: 2278] activity data from GtoPdb

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  • PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586]
  • This target only has 0 pki data point
1 _lig_chart_1 PAC1 receptor Human
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  • VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241]
  • This target only has 1 pki data point
2 _lig_chart_2 VPAC1 receptor Human
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  • VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587]
  • This target only has 1 pki data point
3 _lig_chart_3 VPAC2 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586]
GtoPdb calcium influx in CHO cells stably expressing recombinant receptor - 5 pEC50 >10000 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 5.8 pEC50 1582 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 8.1 pKi 7.4 nM Ki J. Biol. Chem. (2000) 275: 24003-12 [PMID:10801840]
GtoPdb calcium influx in CHO cells stably expressing recombinant receptor - 7.6 pEC50 25.6 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 9.4 pEC50 0.4 nM EC50 J. Biol. Chem. (2000) 275: 24003-12 [PMID:10801840]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 10.2 pEC50 0.06 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 5.6 pKi 2352 nM Ki J. Biol. Chem. (2000) 275: 24003-12 [PMID:10801840]
GtoPdb calcium influx in CHO cells stably expressing recombinant receptor - 5 pEC50 >10000 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 5 pEC50 >10000 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 5.9 pEC50 1222 nM EC50 J. Biol. Chem. (2000) 275: 24003-12 [PMID:10801840]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.