GtoPdb Ligand ID: 9510

Synonyms: GS-5745 | GS5745
Compound class: Antibody
Comment: Gilead Sciences designed andecaliximab (GS-5745), a humanized anti-MMP9 monoclonal antibody, for potential to treat solid tumours and inflammatory disorders [1-2]. GS-5745 inhibits MMP-9 activity by a combination of blocking proenzyme (zymogen) conversion to active enzyme, and allosterically inhibiting active MMP-9 catalytic activity [1].
Compound class Antibody
International Nonproprietary Names
INN number INN
10035 andecaliximab
GS-5745 | GS5745
Database Links
Specialist databases
IMGT/mAb-DB 533
Other databases
GtoPdb PubChem SID 329968449
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