BRD9185 [Ligand Id: 11469] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4064731 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127] | ||||||||
| GtoPdb | - | - | 4.3 | pIC50 | >50000 | nM | IC50 | ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533] |
| ChEMBL | Inhibition of recombinant human DHODH | B | 4.3 | pIC50 | >50000 | nM | IC50 | ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 infected in human blood after 72 hrs by SYBR Green dye based assay | F | 7.8 | pEC50 | 16 | nM | EC50 | ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949] | ||||||||
| GtoPdb | - | - | 7.92 | pIC50 | 12 | nM | IC50 | ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum Dd2 [GtoPdb: 2949] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.8 | pEC50 | 16 | nM | EC50 | ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
