Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL316966 (Camp, Cyclic Adenosine Monophosphate, cyclic AMP) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Rap guanine nucleotide exchange factor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2029197] [GtoPdb: 1292] [UniProtKB: O95398] | ||||||||
ChEMBL | Binding affinity to GST-tagged human EPAC1 CNBD (149 to 318 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by 8-NBD-cAMP based competitive fluorescence assay | B | 5.35 | pKd | 4500 | nM | Kd | J Med Chem (2020) 63: 4762-4775 [PMID:32297742] |
Rap guanine nucleotide exchange factor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2029198] [GtoPdb: 1293] [UniProtKB: Q8WZA2] | ||||||||
ChEMBL | Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis | B | 4.32 | pIC50 | 48000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4038-4043 [PMID:22607683] |
ChEMBL | Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay | B | 4.4 | pIC50 | 40000 | nM | IC50 | J Med Chem (2013) 56: 952-962 [PMID:23286832] |
ChEMBL | Inhibition of EPAC2 (unknown origin) | B | 4.4 | pIC50 | 40000 | nM | IC50 | J Med Chem (2014) 57: 3651-3665 [PMID:24256330] |
CNGA2 in Rat [GtoPdb: 395] [UniProtKB: Q00195] | ||||||||
GtoPdb | - | - | 4.34 | pEC50 | 45700 | nM | EC50 |
J Neurosci (1999) 19: 5332-47 [PMID:10377344]; Neuron (1994) 13: 611-21 [PMID:7522482]; Proc Natl Acad Sci USA (1994) 91: 8890-4 [PMID:7522325]; Sci Signal (2012) 5: ra48 [PMID:22786723] |
CNGA3 in Human [GtoPdb: 396] [UniProtKB: Q16281] | ||||||||
GtoPdb | - | - | 2.88 | pKd | - | - | - |
FEBS Lett (1996) 393: 211-5 [PMID:8814292]; J Biol Chem (2003) 278: 24617-23 [PMID:12730238] |
CNGA3 in Rat [GtoPdb: 396] | ||||||||
GtoPdb | - | - | 3.6 | pKd | - | - | - | J Neurophysiol (2001) 85: 2335-49 [PMID:11387380] |
HCN1 in Mouse [GtoPdb: 400] [UniProtKB: O88704] | ||||||||
GtoPdb | - | - | 7.2 | pKd | - | - | - |
J Gen Physiol (2001) 117: 491-504 [PMID:11331358]; J Gen Physiol (2001) 118: 237-50 [PMID:11524455] |
HCN2 in Mouse [GtoPdb: 401] [UniProtKB: O88703] | ||||||||
GtoPdb | - | - | 6.3 | pKi | - | - | - | Nature (1998) 393: 587-91 [PMID:9634236] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]