hydrochlorothiazide

Ligand id: 4836

Name: hydrochlorothiazide

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: hydrochlorothiazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 135.12
Molecular weight 296.96
XLogP -0.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1959))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
International Nonproprietary Names
INN number INN
841 hydrochlorothiazide
Synonyms
Apo-hydro®
Comments
Hydrochlorothiazide is the prototypical thiazide diuretic drug.
Database Links
CAS Registry No. 58-93-5 (source: Scifinder)
ChEMBL Ligand CHEMBL435
DrugBank Ligand DB00999
GtoPdb PubChem SID 178101538
PubChem CID 3639
RCSB PDB Ligand HCZ
Search Google for chemical match using the InChIKey JZUFKLXOESDKRF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JZUFKLXOESDKRF
Search PubMed clinical trials hydrochlorothiazide
Search PubMed titles hydrochlorothiazide
Search PubMed titles/abstracts hydrochlorothiazide
Search UniChem for chemical match using the InChIKey JZUFKLXOESDKRF-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone JZUFKLXOESDKRF
Wikipedia Hydrochlorothiazide