hydrochlorothiazide   

GtoPdb Ligand ID: 4836

Synonyms: Apo-hydro®
hydrochlorothiazide is an approved drug (FDA (1959))
Compound class: Synthetic organic
Comment: Hydrochlorothiazide is the prototypical thiazide diuretic drug.
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 135.12
Molecular weight 296.96
XLogP -0.47
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES Clc1cc2NCNS(=O)(=O)c2cc1S(=O)(=O)N
Isomeric SMILES Clc1cc2NCNS(=O)(=O)c2cc1S(=O)(=O)N
InChI InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
InChI Key JZUFKLXOESDKRF-UHFFFAOYSA-N
Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1959))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
International Nonproprietary Names
INN number INN
841 hydrochlorothiazide
Synonyms
Apo-hydro®
Database Links
CAS Registry No. 58-93-5 (source: Scifinder)
ChEMBL Ligand CHEMBL435
DrugBank Ligand DB00999
DrugCentral Ligand 1385
GtoPdb PubChem SID 178101538
PubChem CID 3639
RCSB PDB Ligand HCZ
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Wikipedia Hydrochlorothiazide