Synonyms: BRL-14151 | BRL-14151K | BRL14151 | clavulanate | MM 14151
clavulanic acid is an approved drug
Compound class:
Natural product or derivative
Comment: Clavulanic acid is a β-lactamase inhibitor that was isolated from Streptomyces clavuligerus [1]. It is used in combination with β-lactam antibacterials and does not have inherent antibacterial activity. Clavulanic acid can overcome antibacterial resistance in bacteria that secrete β-lactamase. Included in the WHO Essential Medicines list as the mixture of amoxicillin + clavulanic acid (co-amoxiclav).
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Natural product or derivative |
Approved drug? | Yes |
WHO Essential Medicine | WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version. Click to view more information about the WHO Model Lists of Essential Medicines. |
IUPAC Name ![]() |
(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
International Nonproprietary Names ![]() |
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INN number | INN |
4948 | clavulanic acid |
Synonyms ![]() |
BRL-14151 | BRL-14151K | BRL14151 | clavulanate | MM 14151 |
Database Links ![]() |
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Specialist databases | |
Antibiotic DB
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Clavulanic acid |
Other databases | |
CAS Registry No. | 58001-44-8 (source: PubChem) |
ChEBI | CHEBI:48947 |
ChEMBL Ligand | CHEMBL777 |
DrugCentral Ligand | 669 |
GtoPdb PubChem SID | 434122188 |
PubChem CID | 5280980 |
RCSB PDB Ligand | J01 |
Search Google for chemical match using the InChIKey | HZZVJAQRINQKSD-PBFISZAISA-N |
Search Google for chemicals with the same backbone | HZZVJAQRINQKSD |
Search PubMed clinical trials | clavulanic acid |
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UniChem Compound Search for chemical match using the InChIKey | HZZVJAQRINQKSD-PBFISZAISA-N |
UniChem Connectivity Search for chemical match using the InChIKey | HZZVJAQRINQKSD-PBFISZAISA-N |