GNE-3511 [Ligand Id: 9355] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3393333 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
| ChEMBL | Inhibition of JNK1 (unknown origin) | B | 6.89 | pIC50 | 129 | nM | IC50 | J Med Chem (2015) 58: 401-418 [PMID:25341110] |
| GtoPdb | - | - | 6.89 | pIC50 | 129 | nM | IC50 | J Med Chem (2015) 58: 401-18 [PMID:25341110] |
| mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
| ChEMBL | Inhibition of JNK2 (unknown origin) | B | 6.29 | pIC50 | 514 | nM | IC50 | J Med Chem (2015) 58: 401-418 [PMID:25341110] |
| mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
| ChEMBL | Inhibition of JNK3 (unknown origin) | B | 6.44 | pIC50 | 364 | nM | IC50 | J Med Chem (2015) 58: 401-418 [PMID:25341110] |
| GtoPdb | - | - | 6.44 | pIC50 | 364 | nM | IC50 | J Med Chem (2015) 58: 401-18 [PMID:25341110] |
| mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985] | ||||||||
| ChEMBL | Inhibition of MKK4 (unknown origin) | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2015) 58: 401-418 [PMID:25341110] |
| mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733] | ||||||||
| ChEMBL | Inhibition of MKK7 (unknown origin) | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2015) 58: 401-418 [PMID:25341110] |
| mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779] | ||||||||
| ChEMBL | Inhibition of MLK2 (unknown origin) | B | 6.12 | pIC50 | 767 | nM | IC50 | J Med Chem (2015) 58: 401-418 [PMID:25341110] |
| mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584] | ||||||||
| ChEMBL | Inhibition of MLK3 (unknown origin) | B | 6.22 | pIC50 | 602 | nM | IC50 | J Med Chem (2015) 58: 401-418 [PMID:25341110] |
| mitogen-activated protein kinase kinase kinase 12/Mitogen-activated protein kinase kinase kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908389] [GtoPdb: 2072] [UniProtKB: Q12852] | ||||||||
| GtoPdb | - | - | 9.3 | pKi | <0.5 | nM | Ki | J Med Chem (2015) 58: 8182-99 [PMID:26431428] |
| ChEMBL | Inhibition of DLK (unknown origin) | B | 9.3 | pKi | <0.5 | nM | Ki | J Med Chem (2015) 58: 401-418 [PMID:25341110] |
| ChEMBL | Inhibition of human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-based assay | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2015) 58: 401-418 [PMID:25341110] |
| mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192] | ||||||||
| ChEMBL | Inhibition of MLK1 (unknown origin) | B | 7.17 | pIC50 | 67.8 | nM | IC50 | J Med Chem (2015) 58: 401-418 [PMID:25341110] |
| GtoPdb | - | - | 7.17 | pIC50 | 67.8 | nM | IC50 | J Med Chem (2015) 58: 401-18 [PMID:25341110] |
| ribosomal protein S6 kinase B1 in Human [GtoPdb: 1525] [UniProtKB: P23443] | ||||||||
| GtoPdb | - | - | 5.71 | pIC50 | 1940 | nM | IC50 | J Med Chem (2007) 50: 6-9 [PMID:17201405] |
| mitogen-activated protein kinase kinase kinase 13 in Human [GtoPdb: 2073] [UniProtKB: O43283] | ||||||||
| GtoPdb | - | - | 9.3 | pKi | <0.5 | nM | Ki | J Med Chem (2015) 58: 401-18 [PMID:25341110] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
