idarucizumab   Click here for help

GtoPdb Ligand ID: 8298

Synonyms: aDabi-Fab | BI 655075 | Praxbind®
Approved drug
idarucizumab is an approved drug (FDA and EMA (2015))
Compound class: Antibody
Comment: Idarucizumab is a fully humanized antigen-binding fragment (Fab) of an antibody binding to the active metabolite (dabigatran) of the anti-coagulant prodrug dabigatran etexilate [4]. Idarucizumab has been granted FDA Breakthrough Therapy Designation to help expedite its development, as it represents a solution to an unmet clinical need. That is, to be able to reverse the effects of newer direct, oral anticoagulants such as dabigatran etexilate on demand. Antidotes to other direct anticoagulants in development are discussed in [3] and [1] (see also andexanet alfa).
The crystal structure of dabigatran-bound idarucizumab has been resolved at 1.7Å (Protein Data Bank ID 4JN2) [5]. Additional information regarding the invention of idarucizumab is available in patent US8486398 [6].
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Classification Click here for help
Compound class Antibody
Approved drug? Yes (FDA and EMA (2015))
International Nonproprietary Names Click here for help
INN number INN
9698 idarucizumab
Synonyms Click here for help
aDabi-Fab | BI 655075 | Praxbind®
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 462
Other databases
GtoPdb PubChem SID 252166510
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Wikipedia Idarucizumab