neomycin [Ligand Id: 709] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL184618 (Framycetin, Neomycin b, ANTIBIOTIQUE EF 185)
  • Anthrax lethal factor in Bacillus anthracis [ChEMBL: CHEMBL4372] [UniProtKB: P15917]
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  • Human immunodeficiency virus type 1 REV in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3852] [UniProtKB: Q77YF8]
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  • Phosphatidylcholine-retinol O-acyltransferase in Human [ChEMBL: CHEMBL2202] [UniProtKB: O95237]
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  • CaS receptor in Rat [GtoPdb: 54] [UniProtKB: P48442]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Anthrax lethal factor in Bacillus anthracis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4372] [UniProtKB: P15917]
ChEMBL Inhibition of anthrax lethal factor metalloprotease B 6.3 pKi 500 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 5183-5189 [PMID:16870442]
Human immunodeficiency virus type 1 REV in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3852] [UniProtKB: Q77YF8]
ChEMBL Tested for the ability to bind the HIV-1 RRE-RNA construct by fluorescence anisotropy F 6.74 pKd 180 nM Kd Bioorg. Med. Chem. Lett. (2001) 11: 1127-1131 [PMID:11354359]
Menin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1615381] [UniProtKB: O00255]
ChEMBL Binding affinity to menin (unknown origin) by isothermal titration calorimetry analysis B 4.81 pKd 15600 nM Kd Bioorg. Med. Chem. Lett. (2014) 24: 2090-2093 [PMID:24709560]
Phosphatidylcholine-retinol O-acyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2202] [UniProtKB: O95237]
ChEMBL Compound tested in vitro for inhibition of translation using highly active Escherichia coli S30 and a plasmid containing a gene expressing truncated lecithin retinol acyltransferase B 4.83 pIC50 14900 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 901-903 [PMID:12617917]
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
ChEMBL Inhibition of TRPV1-mediated membrane currents in human DRG neurons B 6.4 pIC50 400 nM IC50 MedChemComm (2011) 2: 181-184
CaS receptor in Rat [GtoPdb: 54] [UniProtKB: P48442]
GtoPdb - - 4 pKd - - - Proc Natl Acad Sci USA (1995) 92: 131-5 [PMID:7816802]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]