neomycin [Ligand Id: 709] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL184618 (Actilin, Antibiotic 10676, ANTIBIOTIQUE EF 185, Dekamycin iii, Enterfram, Fradiomycin b, Framidal, Framycetin, Framycin, Framygen, Francetin, Neomycin b)
  • Anthrax lethal factor in Bacillus anthracis [ChEMBL: CHEMBL4372] [UniProtKB: P15917]
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  • Human immunodeficiency virus type 1 REV in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3852] [UniProtKB: Q77YF8]
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  • Phosphatidylcholine-retinol O-acyltransferase in Human [ChEMBL: CHEMBL2202] [UniProtKB: O95237]
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  • CaS receptor in Rat [GtoPdb: 54] [UniProtKB: P48442]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Anthrax lethal factor in Bacillus anthracis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4372] [UniProtKB: P15917]
ChEMBL Inhibition of anthrax lethal factor metalloprotease B 6.3 pKi 500 nM Ki Bioorg Med Chem Lett (2006) 16: 5183-5189 [PMID:16870442]
Human immunodeficiency virus type 1 REV in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3852] [UniProtKB: Q77YF8]
ChEMBL Tested for the ability to bind the HIV-1 RRE-RNA construct by fluorescence anisotropy F 6.74 pKd 180 nM Kd Bioorg Med Chem Lett (2001) 11: 1127-1131 [PMID:11354359]
Menin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1615381] [UniProtKB: O00255]
ChEMBL Binding affinity to menin (unknown origin) by isothermal titration calorimetry analysis B 4.81 pKd 15600 nM Kd Bioorg Med Chem Lett (2014) 24: 2090-2093 [PMID:24709560]
Phosphatidylcholine-retinol O-acyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2202] [UniProtKB: O95237]
ChEMBL Compound tested in vitro for inhibition of translation using highly active Escherichia coli S30 and a plasmid containing a gene expressing truncated lecithin retinol acyltransferase B 4.83 pIC50 14900 nM IC50 Bioorg Med Chem Lett (2003) 13: 901-903 [PMID:12617917]
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
ChEMBL Inhibition of TRPV1-mediated membrane currents in human DRG neurons B 6.4 pIC50 400 nM IC50 Medchemcomm (2011) 2: 181-184
CaS receptor in Rat [GtoPdb: 54] [UniProtKB: P48442]
GtoPdb - - 4 pKd - - - Proc Natl Acad Sci USA (1995) 92: 131-5 [PMID:7816802]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]