ChEMBL ligand: CHEMBL184618 (Actilin, Antibiotic 10676, ANTIBIOTIQUE EF 185, Dekamycin iii, Enterfram, Fradiomycin b, Framidal, Framycetin, Framycin, Framygen, Francetin, Neomycin b)
Anthrax lethal factor in Bacillus anthracis [ChEMBL: CHEMBL4372] [UniProtKB: P15917] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 REV in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3852] [UniProtKB: Q77YF8] There should be some charts here, you may need to enable JavaScript!
Menin in Human [ChEMBL: CHEMBL1615381] [UniProtKB: O00255] There should be some charts here, you may need to enable JavaScript!
Phosphatidylcholine-retinol O-acyltransferase in Human [ChEMBL: CHEMBL2202] [UniProtKB: O95237] There should be some charts here, you may need to enable JavaScript!
TRPV1/Vanilloid receptor in Human [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1] There should be some charts here, you may need to enable JavaScript!
CaS receptor in Rat [GtoPdb: 54] [UniProtKB: P48442] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Anthrax lethal factor in Bacillus anthracis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4372] [UniProtKB: P15917]
ChEMBL	Inhibition of anthrax lethal factor metalloprotease	B	6.3	pKi	500	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5183-5189 [PMID:16870442]
ChEMBL	Binding affinity to Bacillus anthracis lethal factor assessed as inhibition constant	B	8.15	pKi	7	nM	Ki	Eur J Med Chem (2021) 226: 113877-113877 [PMID:34624823]
Human immunodeficiency virus type 1 REV in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3852] [UniProtKB: Q77YF8]
ChEMBL	Tested for the ability to bind the HIV-1 RRE-RNA construct by fluorescence anisotropy	F	6.74	pKd	180	nM	Kd	Bioorg Med Chem Lett (2001) 11: 1127-1131 [PMID:11354359]
Menin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1615381] [UniProtKB: O00255]
ChEMBL	Binding affinity to menin (unknown origin) by isothermal titration calorimetry analysis	B	4.81	pKd	15600	nM	Kd	Bioorg Med Chem Lett (2014) 24: 2090-2093 [PMID:24709560]
Phosphatidylcholine-retinol O-acyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2202] [UniProtKB: O95237]
ChEMBL	Compound tested in vitro for inhibition of translation using highly active Escherichia coli S30 and a plasmid containing a gene expressing truncated lecithin retinol acyltransferase	B	4.83	pIC50	14900	nM	IC50	Bioorg Med Chem Lett (2003) 13: 901-903 [PMID:12617917]
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
ChEMBL	Inhibition of TRPV1-mediated membrane currents in human DRG neurons	B	6.4	pIC50	400	nM	IC50	Medchemcomm (2011) 2: 181-184
CaS receptor in Rat [GtoPdb: 54] [UniProtKB: P48442]
GtoPdb	-	-	4	pKd	-	-	-	Proc Natl Acad Sci USA (1995) 92: 131-5 [PMID:7816802]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]