m-chlorophenylpiperazine [Ligand Id: 142] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL478 (1-M-Chlorophenyl Piperazine Metabolite, Chlorophenylpiperazine, mCPP) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Binding affinity for Beta-1 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine ventricular muscle in the presence of 1 uM zinterol | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (1992) 35: 743-750 [PMID:1347318] |
| Beta-2 adrenergic receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2289] [UniProtKB: P54833] | ||||||||
| ChEMBL | Binding affinity towards Beta-2 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine lung tissue in the presence of 0.1 uM metoprolol | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (1992) 35: 743-750 [PMID:1347318] |
| D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
| ChEMBL | Binding affinity at rat Dopamine receptor D1 by [3H]SCH-23390 displacement. | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (1989) 32: 1052-1056 [PMID:2565400] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity to D2L receptor (unknown origin) assessed as inhibition constant | B | 5 | pKi | >10000 | nM | Ki | Eur J Med Chem (2022) 235: 114319-114319 [PMID:35367707] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Binding affinity against rat Dopamine receptor D2. | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (1989) 32: 1052-1056 [PMID:2565400] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5HT1A receptor | B | 7 | pKd | 100 | nM | Kd | J Med Chem (2009) 52: 6107-6125 [PMID:19754201] |
| ChEMBL | Binding affinity to 5-HT1AR (unknown origin) assessed as inhibition constant | B | 7.38 | pKi | 42 | nM | Ki | Eur J Med Chem (2022) 235: 114319-114319 [PMID:35367707] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a radioligand. | B | 5.62 | pKi | 2400 | nM | Ki | J Med Chem (1987) 30: 1-12 [PMID:3543362] |
| ChEMBL | Displacement of radioligand [3H]2-(di-N-propylamino)-8-hydroxytetralin from 5-hydroxytryptamine 1A receptor in rat frontal cortex homogenate (experiment 1) | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (1993) 36: 2751-2760 [PMID:8410989] |
| ChEMBL | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement | B | 6.84 | pKi | 144.54 | nM | Ki | J Med Chem (1996) 39: 126-134 [PMID:8568799] |
| ChEMBL | Displacement of radioligand [3H]2-(di-N-propylamino)-8-hydroxytetralin from 5-hydroxytryptamine 1A receptor in rat frontal cortex homogenate (experiment 2) | B | 6.84 | pKi | 143 | nM | Ki | J Med Chem (1993) 36: 2751-2760 [PMID:8410989] |
| ChEMBL | In vitro ability to displace [3H]8-hydroxy-2-(di-n-propylamino) tetralin binding from 5-hydroxytryptamine 1A receptor site in rat brain hippocampus | B | 6.84 | pKi | 143 | nM | Ki | J Med Chem (1992) 35: 2369-2374 [PMID:1535661] |
| ChEMBL | Binding affinity towards rat 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT radioligand. | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (1996) 39: 4439-4450 [PMID:8893838] |
| ChEMBL | Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (1988) 31: 1968-1971 [PMID:3172131] |
| ChEMBL | Binding affinity at rat 5-hydroxytryptamine 1A receptor by [3H]WB-4101 displacement. | B | 7.64 | pKi | 23 | nM | Ki | J Med Chem (1989) 32: 1052-1056 [PMID:2565400] |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] | ||||||||
| ChEMBL | Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand. | B | 7.12 | pKi | 75 | nM | Ki | J Med Chem (1987) 30: 1-12 [PMID:3543362] |
| ChEMBL | Binding affinity at rat 5-hydroxytryptamine 1B receptor by [3H]5-HT displacement. | B | 8.36 | pKi | 4.4 | nM | Ki | J Med Chem (1989) 32: 1052-1056 [PMID:2565400] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Binding affinity to 5HT2A (unknown origin) | B | 6.56 | pKi | 273 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 914-920 [PMID:26748694] |
| ChEMBL | Affinity for human 5-hydroxytryptamine 2A receptor expressed in mammalian cell line | B | 7.27 | pKi | 54 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| ChEMBL | Displacement of [125I]DOI from human 5HT2A | B | 7.27 | pKi | 54 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207] |
| ChEMBL | Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cells | B | 7.32 | pKi | 48 | nM | Ki | J Med Chem (2007) 50: 1365-1379 [PMID:17315987] |
| ChEMBL | Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in HEK293E cells | B | 7.32 | pKi | 48 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 1128-1133 [PMID:20022752] |
| ChEMBL | Binding affinity to 5-HT2AR (unknown origin) assessed as inhibition constant | B | 7.49 | pKi | 32 | nM | Ki | Eur J Med Chem (2022) 235: 114319-114319 [PMID:35367707] |
| GtoPdb | - | - | 7.5 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Biochem Pharmacol (1996) 51: 71-6 [PMID:8534270]; Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 1-6 [PMID:9933142] |
| ChEMBL | Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay | F | 6.54 | pEC50 | 290 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 1128-1133 [PMID:20022752] |
| ChEMBL | Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay | F | 6.54 | pEC50 | 290 | nM | EC50 | J Med Chem (2007) 50: 1365-1379 [PMID:17315987] |
| ChEMBL | Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay | F | 6.78 | pEC50 | 167 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 5791-5795 [PMID:19716297] |
| ChEMBL | Binding to human 5HT2A receptor expressed in CHO cells | B | 7.12 | pEC50 | 75 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207] |
| ChEMBL | Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader | F | 7.12 | pEC50 | 75 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| ChEMBL | Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation | F | 7.2 | pEC50 | 63.1 | nM | EC50 | J Med Chem (2008) 51: 305-313 [PMID:18095642] |
| ChEMBL | Agonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay | F | 8.14 | pEC50 | 7.2 | nM | EC50 | Eur J Med Chem (2013) 63: 558-569 [PMID:23537943] |
| 5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| GtoPdb | - | - | 6.4 | pKi | - | - | - | Circulation (2000) 102: 2836-41 [PMID:11104741] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line | B | 7.49 | pKi | 32 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| ChEMBL | Displacement of [3H]5-HT from human 5HT2B | B | 7.49 | pKi | 32 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207] |
| ChEMBL | Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2007) 50: 1365-1379 [PMID:17315987] |
| ChEMBL | Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 1128-1133 [PMID:20022752] |
| GtoPdb | - | - | 8.5 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Circulation (2000) 102: 2836-41 [PMID:11104741]; Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 1-6 [PMID:9933142]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 17-24 [PMID:9459568]; Br J Pharmacol (2003) 140: 277-84 [PMID:12970106] |
| ChEMBL | Binding to human 5HT2B receptor expressed in CHO cells | B | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207] |
| ChEMBL | Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader | F | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| ChEMBL | Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay | F | 6.54 | pEC50 | 287 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 1128-1133 [PMID:20022752] |
| ChEMBL | Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay | F | 6.54 | pEC50 | 287 | nM | EC50 | J Med Chem (2007) 50: 1365-1379 [PMID:17315987] |
| ChEMBL | Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay | F | 6.9 | pEC50 | 125 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 5791-5795 [PMID:19716297] |
| ChEMBL | Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay | F | 6.9 | pEC50 | 125 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 4999-5003 [PMID:19646865] |
| ChEMBL | Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation | F | 7.4 | pEC50 | 39.81 | nM | EC50 | J Med Chem (2008) 51: 305-313 [PMID:18095642] |
| 5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994] | ||||||||
| GtoPdb | - | - | 7.6 | pKi | - | - | - | Mol Pharmacol (1993) 43: 419-26 [PMID:8450835] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Binding affinity to 5HT2C (unknown origin) | B | 7.56 | pKi | 27.7 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 914-920 [PMID:26748694] |
| ChEMBL | Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cells | B | 7.77 | pKi | 17 | nM | Ki | J Med Chem (2007) 50: 1365-1379 [PMID:17315987] |
| ChEMBL | Displacement of [125I]DOI from human recombinant 5HT2C receptor expressed in HEK293E cells | B | 7.77 | pKi | 17 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 1128-1133 [PMID:20022752] |
| ChEMBL | Affinity for human 5-hydroxytryptamine 2C receptor expressed in mammalian cell line | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| ChEMBL | Displacement of [3H]5-HT from human 5HT2C | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207] |
| ChEMBL | Displacement of [125I]DOI from recombinant human 5-HT2C receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting | B | 8.1 | pKi | 7.94 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 5877-5882 [PMID:27864071] |
| GtoPdb | - | - | 8.5 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 1-6 [PMID:9933142]; Br J Pharmacol (2003) 140: 277-84 [PMID:12970106]; J Neurochem (1999) 72: 2127-34 [PMID:10217294]; Synapse (2000) 35: 144-50 [PMID:10611640]; Eur J Pharmacol (2004) 483: 37-43 [PMID:14709324] |
| ChEMBL | Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay | F | 6.77 | pEC50 | 170 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 4999-5003 [PMID:19646865] |
| ChEMBL | Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay | F | 6.77 | pEC50 | 170 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 5791-5795 [PMID:19716297] |
| ChEMBL | Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader | F | 7.59 | pEC50 | 26 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| ChEMBL | Binding to human 5HT2C receptor expressed in CHO cells | B | 7.59 | pEC50 | 26 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207] |
| ChEMBL | Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay | F | 7.82 | pEC50 | 15 | nM | EC50 | J Med Chem (2007) 50: 1365-1379 [PMID:17315987] |
| ChEMBL | Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay | F | 7.82 | pEC50 | 15 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 1128-1133 [PMID:20022752] |
| ChEMBL | Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay | F | 7.82 | pEC50 | 15 | nM | EC50 | J Med Chem (2017) 60: 6166-6190 [PMID:28635286] |
| ChEMBL | Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting | F | 7.9 | pEC50 | 12.59 | nM | EC50 | Bioorg Med Chem Lett (2016) 26: 5877-5882 [PMID:27864071] |
| ChEMBL | Agonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay | F | 8.09 | pEC50 | 8.1 | nM | EC50 | Eur J Med Chem (2013) 63: 558-569 [PMID:23537943] |
| ChEMBL | Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation | F | 8.1 | pEC50 | 7.94 | nM | EC50 | J Med Chem (2008) 51: 305-313 [PMID:18095642] |
| 5-HT2C receptor in Rat [GtoPdb: 8] [UniProtKB: P08909] | ||||||||
| GtoPdb | - | - | 7.2 | pKi | - | - | - | Circulation (2000) 102: 2836-41 [PMID:11104741] |
| 5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377, 374, 373, 376, 375] [UniProtKB: A5X5Y0, O95264, P46098, Q70Z44, Q8WXA8] | ||||||||
| ChEMBL | Compound was tested for the inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells | B | 7.21 | pKi | 62 | nM | Ki | J Med Chem (1996) 39: 4017-4026 [PMID:8831767] |
| 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3597] [GtoPdb: 10] [UniProtKB: P30966] | ||||||||
| ChEMBL | Binding affinity towards murine 5-hydroxytryptamine 5A receptor | B | 5.06 | pKi | 8700 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| ChEMBL | Binding affinity towards mouse 5-hydroxytryptamine 5A receptor was evaluated using [3H]LSD as radioligand | B | 5.06 | pKi | 8700 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [125I]-2-iodo LSD as radioligand | B | 5.64 | pKi | 2300 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| ChEMBL | Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constant | B | 5.76 | pKi | 1748 | nM | Ki | Eur J Med Chem (2022) 235: 114319-114319 [PMID:35367707] |
| 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] | ||||||||
| GtoPdb | - | - | 5.6 | pKi | - | - | - | Mol Pharmacol (1993) 43: 320-7 [PMID:7680751] |
| 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
| ChEMBL | Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor | B | 6.52 | pKi | 304 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| ChEMBL | Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant | B | 6.79 | pKi | 163 | nM | Ki | Eur J Med Chem (2022) 235: 114319-114319 [PMID:35367707] |
| 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] | ||||||||
| ChEMBL | Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells | B | 6.45 | pKi | 352 | nM | Ki | J Med Chem (2012) 55: 6375-6380 [PMID:22738316] |
| GtoPdb | - | - | 6.6 | pKi | - | - | - | J Biol Chem (1993) 268: 18200-4 [PMID:8394362] |
| SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| ChEMBL | Binding affinity to SERT (unknown origin) | B | 6.57 | pKi | 271 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 914-920 [PMID:26748694] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
| ChEMBL | Binding affinity towards sigma receptor in guinea pig brain membranes using [3H]DTG as radioligand | B | 5.21 | pKi | 6150 | nM | Ki | J Med Chem (1991) 34: 3360-3365 [PMID:1662725] |
| 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| GtoPdb | - | - | 6.7 | pKi | - | - | - | Mol Pharmacol (1991) 40: 143-8 [PMID:1652050] |
| 5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566] | ||||||||
| GtoPdb | - | - | 5.4 | pKi | - | - | - | Eur J Pharmacol (2004) 484: 127-39 [PMID:14744596] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
