ChEMBL ligand: CHEMBL1014 (Amias, Atacand, Candesartan 1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester, Candesartan cilexetil, NSC-758697, Ratacand, TCV-116)
Angiotensin II type 1a (AT-1a) receptor in Rabbit [ChEMBL: CHEMBL3948] [UniProtKB: P34976] There should be some charts here, you may need to enable JavaScript!
ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
Cruzipain in Trypanosoma cruzi [ChEMBL: CHEMBL3563] [UniProtKB: P25779] There should be some charts here, you may need to enable JavaScript!
DNA polymerase eta in Human [ChEMBL: CHEMBL5542] [UniProtKB: Q9Y253] There should be some charts here, you may need to enable JavaScript!
DNA polymerase iota in Human [ChEMBL: CHEMBL5391] [UniProtKB: Q9UNA4] There should be some charts here, you may need to enable JavaScript!
DNA polymerase kappa in Human [ChEMBL: CHEMBL5365] [UniProtKB: Q9UBT6] There should be some charts here, you may need to enable JavaScript!
NEDD8-activating enzyme E1 regulatory subunit in Human [ChEMBL: CHEMBL2016431] [UniProtKB: Q13564] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Angiotensin II type 1a (AT-1a) receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3948] [UniProtKB: P34976]
ChEMBL	Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232]
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL	Inhibition of human ABCG2 expressed in dog MDCK-II-BCRP cells mediated pheophorbide A efflux and measured after 60 mins using pheophorbide A as fluorescent substrate by flow cytometry	B	5.3	pIC50	5000	nM	IC50	Eur J Med Chem (2022) 237: 114346-114346 [PMID:35483322]
Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779]
ChEMBL	Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in absence of Triton X-100	B	4.38	pIC50	42000	nM	IC50	J Med Chem (2010) 53: 4259-4265 [PMID:20426472]
DNA polymerase eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5542] [UniProtKB: Q9Y253]
ChEMBL	Inhibition of human DNA polymerase eta (1 to 437 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition measured after 30 mins in presence of dCTP and dGTP by radioactive gel-based primer extension assay	B	4.95	pIC50	11200	nM	IC50	J Med Chem (2016) 59: 9321-9336 [PMID:27362876]
DNA polymerase iota in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5391] [UniProtKB: Q9UNA4]
ChEMBL	Inhibition of human DNA polymerase iota preincubated for 15 mins followed by replicating non-damaged DNA substrate addition measured after 30 mins in presence of dCTP and dGTP by radioactive gel-based primer extension assay	B	5.21	pIC50	6200	nM	IC50	J Med Chem (2016) 59: 9321-9336 [PMID:27362876]
DNA polymerase kappa in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5365] [UniProtKB: Q9UBT6]
ChEMBL	Inhibition of human DNA polymerase kappa (19 to 526 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition measured after 30 mins in presence of dCTP and dGTP by radioactive gel-based primer extension assay	B	5.04	pIC50	9200	nM	IC50	J Med Chem (2016) 59: 9321-9336 [PMID:27362876]
ChEMBL	Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions preincubated for 15 mins followed by DNA substrate addition measured after 30 mins in presence of dCTP and dGTP by radioactive gel-based primer extension assay	B	5.25	pIC50	5600	nM	IC50	J Med Chem (2016) 59: 9321-9336 [PMID:27362876]
NEDD8-activating enzyme E1 regulatory subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2016431] [UniProtKB: Q13564]
ChEMBL	Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed by ATP addition and measured after 30 mins by immunoblot analysis	B	4.78	pIC50	16430	nM	IC50	Eur J Med Chem (2021) 210: 112964-112964 [PMID:33129593]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Agonist activity at human PPARgammaDEF receptor expressed in african green monkey COS7 cells transfected with pGal5-TK-pGL3/pRenilla-CMV assessed as intrinsic activity measured after 39 hrs by dual luciferase reporter assay	B	5.38	pEC50	4200	nM	EC50	Eur J Med Chem (2020) 195: 112258-112258 [PMID:32272420]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]