5-oxo-15-HETE [Ligand Id: 6167] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1682258 (5-oxo-15-HETE) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OXE receptor/Oxoeicosanoid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628461] [GtoPdb: 271] [UniProtKB: Q8TDS5] | ||||||||
| ChEMBL | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization | F | 7.25 | pEC50 | 56 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 1857-1860 [PMID:21316960] |
| GtoPdb | - | - | 7.7 | pEC50 | 20 | nM | EC50 |
Biochim Biophys Acta (1994) 1201: 505-15 [PMID:7803484]; J Biol Chem (1993) 268: 9280-6 [PMID:8387490]; J Biol Chem (1995) 270: 15029-36 [PMID:7797484]; J Immunol (1996) 156: 336-42 [PMID:8598482] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
