dexlansoprazole [Ligand Id: 5487] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201863 (T-168390, Dexilant solutab, Kapidex, Dexlansoprazole, Lansoprazole r-form, Dexilant, TAK-390)
  • Endo-beta-N-acetylglucosaminidase in Human [ChEMBL: CHEMBL5172] [UniProtKB: Q8NFI3]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1201863_lig_chart_1 Endo-beta-N-acetylglucosaminidase Human
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  • NAD(+) hydrolase SARM1 in Human [ChEMBL: CHEMBL4523350] [UniProtKB: Q6SZW1]
  • This target only has 0 pki data point
  • 0
2 CHEMBL1201863_lig_chart_2 NAD(+) hydrolase SARM1 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Endo-beta-N-acetylglucosaminidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5172] [UniProtKB: Q8NFI3]
ChEMBL Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreated for 15 mins followed by substrate addition after 90 mins by SDS-PAGE analysis B 4.6 pIC50 25000 nM IC50 Bioorg Med Chem Lett (2017) 27: 2962-2966 [PMID:28512024]
NAD(+) hydrolase SARM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523350] [UniProtKB: Q6SZW1]
ChEMBL Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring NAD depletion pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis B 5.46 pIC50 3500 nM IC50 WO-2018057989-A1. INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF (null)
ChEMBL Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring maximal ADPR conversion pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis B 5.48 pIC50 3300 nM IC50 WO-2018057989-A1. INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF (null)

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]