A-123189 [Ligand Id: 491] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL13856 (A-123189)
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
  • Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
  • 8.48
1 CHEMBL13856_lig_chart_1 Alpha-1a adrenergic receptor HumanBovineRat
There should be some charts here, you may need to enable JavaScript!
  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
  • 0
2 CHEMBL13856_lig_chart_2 Alpha-1b adrenergic receptor HumanRat
There should be some charts here, you may need to enable JavaScript!
  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
  • 9.78
3 CHEMBL13856_lig_chart_3 Alpha-1d adrenergic receptor HumanRat
There should be some charts here, you may need to enable JavaScript!
  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
  • This target only has 1 pki data point
  • 7.08
4 CHEMBL13856_lig_chart_4 Alpha-2a adrenergic receptor Human
There should be some charts here, you may need to enable JavaScript!
  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Rat [ChEMBL: CHEMBL266] [GtoPdb: 26] [UniProtKB: P19328]
  • This target only has 1 pki data point
  • 7.18
5 CHEMBL13856_lig_chart_5 Alpha-2b adrenergic receptor Rat
There should be some charts here, you may need to enable JavaScript!
  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
  • This target only has 1 pki data point
  • 7.09
6 CHEMBL13856_lig_chart_6 Alpha-2c adrenergic receptor Human
There should be some charts here, you may need to enable JavaScript!
  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
  • This target only has 1 pki data point
  • 4.91
7 CHEMBL13856_lig_chart_7 Dopamine D1 receptor Rat
There should be some charts here, you may need to enable JavaScript!
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
  • This target only has 1 pki data point
  • 7.77
8 CHEMBL13856_lig_chart_8 Dopamine D2 receptor Rat
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active B 8.38 pKi 4.2 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 657-664 [PMID:15664832]
ChEMBL Binding affinity for human Alpha-1A adrenergic receptor B 8.38 pKi 4.17 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
GtoPdb - - 8.4 pKi - - - Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL Binding affinity towards bovine Alpha-1A adrenergic receptor B 9.46 pKi 0.35 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL In vitro functional activity at Alpha-1A adrenergic receptor in rat vas deferens B 8.36 pKd 4.37 nM Kd Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
ChEMBL Binding affinity towards rat Alpha-1A adrenergic receptor B 8.46 pKi 3.47 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
GtoPdb - - 8.5 pKi - - - Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
GtoPdb - - 8 pKi - - - Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]
ChEMBL Binding affinity towards human Alpha-1B adrenergic receptor B 8.04 pKi 9.09 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL In vitro functional activity at Alpha-1B adrenergic receptor in rat spleen F 8.76 pKd 1.74 nM Kd Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
GtoPdb - - 9.5 pKi - - - Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]
ChEMBL Binding affinity towards human Alpha-1D adrenergic receptor B 9.51 pKi 0.31 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
ChEMBL In vitro functional activity at Alpha-1D receptor in rat aorta B 10.7 pKd 0.02 nM Kd Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
ChEMBL Binding affinity towards rat Alpha-1D adrenergic receptor B 9.77 pKi 0.17 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
GtoPdb - - 9.8 pKi - - - Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptor B 7.08 pKi 82.5 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL266] [GtoPdb: 26] [UniProtKB: P19328]
ChEMBL Ancillary Binding affinity towards rat alpha-2B receptor B 7.18 pKi 66.6 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL Ancillary Binding affinity to cloned human Alpha-2C adrenergic receptor B 7.09 pKi 82 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL Ancillary Binding affinity to rat Dopamine receptor D1 B 4.91 pKi 12300 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Ancillary Binding affinity towards rat Dopamine receptor D2 B 7.77 pKi 17 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1119-1121 [PMID:11354357]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]