ABD-1970 [Ligand Id: 11816] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4517565
  • PLA2-G7/LDL-associated phospholipase A2 in Human [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093]
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  • αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Human [ChEMBL: CHEMBL2189127] [GtoPdb: 2919] [UniProtKB: Q9BV23]
  • αβ-Hydrolase 6 in Mouse [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
  • αβ-Hydrolase 6 in Rat [GtoPdb: 2919] [UniProtKB: Q5XI64]
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  • Monoacylglycerol lipase/Monoglyceride lipase in Human [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685]
  • Monoacylglycerol lipase/Monoglyceride lipase in Mouse [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678]
  • Monoacylglycerol lipase in Rat [GtoPdb: 1399] [UniProtKB: Q8R431]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PLA2-G7/LDL-associated phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093]
ChEMBL Inhibition of PLA2G7 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay B 5.2 pIC50 6300 nM IC50 J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189127] [GtoPdb: 2919] [UniProtKB: Q9BV23]
ChEMBL Inhibition of ABHD6 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay B 5.68 pIC50 2100 nM IC50 J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
αβ-Hydrolase 6 in Mouse [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
GtoPdb - - 5.49 pIC50 3200 nM IC50 J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
αβ-Hydrolase 6 in Rat [GtoPdb: 2919] [UniProtKB: Q5XI64]
GtoPdb - - 6.1 pIC50 800 nM IC50 J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
Monoacylglycerol lipase/Monoglyceride lipase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685]
GtoPdb hMAGL from PC3 cell lysate - 7.74 pIC50 18 nM IC50 J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
ChEMBL Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay B 7.82 pIC50 15 nM IC50 J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
Monoacylglycerol lipase/Monoglyceride lipase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678]
ChEMBL Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay B 7.54 pIC50 29 nM IC50 J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
GtoPdb MAGL in mouse brain - 7.82 pIC50 15 nM IC50 J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
Monoacylglycerol lipase in Rat [GtoPdb: 1399] [UniProtKB: Q8R431]
GtoPdb MAGL in rat brain cortex - 8.52 pIC50 3 nM IC50 J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]