ChEMBL ligand: CHEMBL4517565
PLA2-G7/LDL-associated phospholipase A2 in Human [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093] There should be some charts here, you may need to enable JavaScript!
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Human [ChEMBL: CHEMBL2189127] [GtoPdb: 2919] [UniProtKB: Q9BV23] αβ-Hydrolase 6 in Mouse [GtoPdb: 2919] [UniProtKB: Q8R2Y0] αβ-Hydrolase 6 in Rat [GtoPdb: 2919] [UniProtKB: Q5XI64] There should be some charts here, you may need to enable JavaScript!
Monoacylglycerol lipase/Monoglyceride lipase in Human [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685] Monoacylglycerol lipase/Monoglyceride lipase in Mouse [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678] Monoacylglycerol lipase in Rat [GtoPdb: 1399] [UniProtKB: Q8R431] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
PLA2-G7/LDL-associated phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093]
ChEMBL	Inhibition of PLA2G7 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay	B	5.2	pIC50	6300	nM	IC50	J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189127] [GtoPdb: 2919] [UniProtKB: Q9BV23]
ChEMBL	Inhibition of ABHD6 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay	B	5.68	pIC50	2100	nM	IC50	J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
αβ-Hydrolase 6 in Mouse [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
GtoPdb	-	-	5.49	pIC50	3200	nM	IC50	J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
αβ-Hydrolase 6 in Rat [GtoPdb: 2919] [UniProtKB: Q5XI64]
GtoPdb	-	-	6.1	pIC50	800	nM	IC50	J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
Monoacylglycerol lipase/Monoglyceride lipase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685]
GtoPdb	hMAGL from PC3 cell lysate	-	7.74	pIC50	18	nM	IC50	J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
ChEMBL	Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay	B	7.82	pIC50	15	nM	IC50	J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
Monoacylglycerol lipase/Monoglyceride lipase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678]
ChEMBL	Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay	B	7.54	pIC50	29	nM	IC50	J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
GtoPdb	MAGL in mouse brain	-	7.82	pIC50	15	nM	IC50	J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
Monoacylglycerol lipase in Rat [GtoPdb: 1399] [UniProtKB: Q8R431]
GtoPdb	MAGL in rat brain cortex	-	8.52	pIC50	3	nM	IC50	J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]