ChEMBL ligand: CHEMBL4517565
PLA2-G7/LDL-associated phospholipase A2 in Human [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093] There should be some charts here, you may need to enable JavaScript!
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Human [ChEMBL: CHEMBL2189127] [GtoPdb: 2919] [UniProtKB: Q9BV23] αβ-Hydrolase 6 in Mouse [GtoPdb: 2919] [UniProtKB: Q8R2Y0] αβ-Hydrolase 6 in Rat [GtoPdb: 2919] [UniProtKB: Q5XI64] There should be some charts here, you may need to enable JavaScript!
monoacylglycerol lipase/Monoglyceride lipase in Human [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685] monoacylglycerol lipase/Monoglyceride lipase in Mouse [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678] monoacylglycerol lipase in Rat [GtoPdb: 1399] [UniProtKB: Q8R431] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
PLA2-G7/LDL-associated phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093]
ChEMBL	Inhibition of PLA2G7 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay	B	5.2	pIC50	6300	nM	IC50	J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189127] [GtoPdb: 2919] [UniProtKB: Q9BV23]
ChEMBL	Inhibition of ABHD6 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay	B	5.68	pIC50	2100	nM	IC50	J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
αβ-Hydrolase 6 in Mouse [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
GtoPdb	-	-	5.49	pIC50	3200	nM	IC50	J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
αβ-Hydrolase 6 in Rat [GtoPdb: 2919] [UniProtKB: Q5XI64]
GtoPdb	-	-	6.1	pIC50	800	nM	IC50	J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
monoacylglycerol lipase/Monoglyceride lipase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685]
GtoPdb	hMAGL from PC3 cell lysate	-	7.74	pIC50	18	nM	IC50	J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
ChEMBL	Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay	B	7.82	pIC50	15	nM	IC50	J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
monoacylglycerol lipase/Monoglyceride lipase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678]
ChEMBL	Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay	B	7.54	pIC50	29	nM	IC50	J Med Chem (2018) 61: 9062-9084 [PMID:30067909]
GtoPdb	MAGL in mouse brain	-	7.82	pIC50	15	nM	IC50	J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]
monoacylglycerol lipase in Rat [GtoPdb: 1399] [UniProtKB: Q8R431]
GtoPdb	MAGL in rat brain cortex	-	8.52	pIC50	3	nM	IC50	J Pharmacol Exp Ther (2018) 367: 494-508 [PMID:30305428]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]