BPH-628 [Ligand Id: 3188] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL262616 ((1-Hydroxy-1-Phosphono-2-[1,1';4',1'']Terphenyl-3-Yl-Ethyl)-Phosphonic Acid)
  • Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051]
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  • geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051]
ChEMBL Binding affinity to Saccharomyces cerevisiae GGPPS B 7.52 pKi 30 nM Ki Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
ChEMBL Inhibition of Saccharomyces cerevisiae GGPPS B 7.15 pIC50 70 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL Binding affinity to human GGPPS B 7.7 pKi 20 nM Ki Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
ChEMBL Inhibition of human recombinant geranylgeranyl diphosphate synthase B 6.1 pIC50 794.33 nM IC50 J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
GtoPdb Inhibition of human GGPPS; radiometric assay - 6.14 pIC50 720 nM IC50 Proc Natl Acad Sci USA (2007) 104: 10022-7 [PMID:17535895]
GtoPdb Inhibition of human recombinant geranylgeranyl diphosphate synthase - 6.14 pIC50 720 nM IC50 J Med Chem (2008) 51: 5594-607 [PMID:18800762]
ChEMBL Inhibition of human GGPPS B 6.14 pIC50 720 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
ChEMBL Inhibition of human recombinant geranylgeranyl diphosphate synthase B 6.14 pIC50 720 nM IC50 J Med Chem (2008) 51: 5594-5607 [PMID:18800762]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]