zucapsaicin [Ligand Id: 11576] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL313971 (Zucapsaicin)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
ChEMBL Displacement of [3H]-RTX from human TRPV1 expressed in CHO cells incubated for 60 mins by radioligand competition assay based scintillation counting method B 5.97 pKi 1080 nM Ki J Med Chem (2020) 63: 418-424 [PMID:31702924]
ChEMBL Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method B 7.55 pEC50 28.2 nM EC50 J Med Chem (2020) 63: 418-424 [PMID:31702924]
GtoPdb Agonist activity at human TRPV1, determined as increase in [45]Ca2+ uptake in CHO cells expressing the ion channel - 7.55 pEC50 28.2 nM EC50 J Med Chem (2020) 63: 418-424 [PMID:31702924]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]