zucapsaicin [Ligand Id: 11576] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL313971 (Civamide, Zucapsaicin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1] | ||||||||
| ChEMBL | Displacement of [3H]-RTX from human TRPV1 expressed in CHO cells incubated for 60 mins by radioligand competition assay based scintillation counting method | B | 5.97 | pKi | 1080 | nM | Ki | J Med Chem (2020) 63: 418-424 [PMID:31702924] |
| ChEMBL | Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method | B | 7.55 | pEC50 | 28.2 | nM | EC50 | J Med Chem (2020) 63: 418-424 [PMID:31702924] |
| GtoPdb | Agonist activity at human TRPV1, determined as increase in [45]Ca2+ uptake in CHO cells expressing the ion channel | - | 7.55 | pEC50 | 28.2 | nM | EC50 | J Med Chem (2020) 63: 418-424 [PMID:31702924] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
