ChEMBL ligand: CHEMBL385517 (BMS-477118, Saxagliptin anhydrous, SBMS-477118)
Dipeptidyl-peptidase 7/Dipeptidyl peptidase 2 in Human [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 4/Dipeptidyl peptidase 4 in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] dipeptidyl peptidase 4/Dipeptidyl peptidase 4 in Mouse [ChEMBL: CHEMBL3883] [GtoPdb: 1612] [UniProtKB: P28843] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 8/Dipeptidyl peptidase 8 in Human [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 9/Dipeptidyl peptidase 9 in Human [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2] There should be some charts here, you may need to enable JavaScript!
prolyl endopeptidase/Prolyl endopeptidase in Human [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147] There should be some charts here, you may need to enable JavaScript!
fibroblast activation protein alpha/Prolyl endopeptidase FAP in Human [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Dipeptidyl-peptidase 7/Dipeptidyl peptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4]
ChEMBL	Binding affinity to DPP-2 (unknown origin) assessed as inhibition constant	B	4.52	pKi	>30000	nM	Ki	J Med Chem (2023) 66: 11593-11631 [PMID:37647598]
ChEMBL	Inhibition of human DPP2 using Lys-Ala-AMC as substrate by fluorimetric analysis	B	4.52	pIC50	>30000	nM	IC50	Bioorg Med Chem (2012) 20: 5864-5883 [PMID:22938786]
dipeptidyl peptidase 4/Dipeptidyl peptidase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL	Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetry	B	7.8	pKd	15.9	nM	Kd	J Med Chem (2016) 59: 7466-7477 [PMID:27438064]
ChEMBL	Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysis	B	9.52	pKd	0.3	nM	Kd	J Med Chem (2016) 59: 7466-7477 [PMID:27438064]
ChEMBL	Binding affinity to human DPP-4 using gly-pro-pNA as substrate assessed as inhibition constant	B	8.89	pKi	1.3	nM	Ki	J Med Chem (2023) 66: 11593-11631 [PMID:37647598]
GtoPdb	-	-	9.2	pKi	0.6	nM	Ki	Curr Drug Targets (2009) 10: 71-87 [PMID:19149538]
ChEMBL	In vitro inhibition constant against human Dipeptidyl peptidase IV	B	9.22	pKi	0.6	nM	Ki	J Med Chem (2005) 48: 5025-5037 [PMID:16033281]
ChEMBL	Inhibition of human DPP4 expressed in Caco-2 cells	B	9.22	pKi	0.6	nM	Ki	J Med Chem (2006) 49: 6416-6420 [PMID:17034148]
ChEMBL	Inhibition of human DPP4	B	9.22	pKi	0.6	nM	Ki	Bioorg Med Chem Lett (2007) 17: 6476-6480 [PMID:17937986]
ChEMBL	Inhibition of human DPP4	B	9.22	pKi	0.6	nM	Ki	Bioorg Med Chem (2009) 17: 1783-1802 [PMID:19217790]
ChEMBL	Inhibition of DPP4	B	9.22	pKi	0.6	nM	Ki	Eur J Med Chem (2009) 44: 3318-3322 [PMID:19375196]
ChEMBL	Inhibition of DPP4 in human Caco2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate after 1 hr by fluorescence assay	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2013) 21: 2795-2825 [PMID:23623674]
ChEMBL	Inhibition of human recombinant DPP-4 expressed in human Caco-2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate measured after 1 hrs by fluorescence based assay	B	7.3	pIC50	50	nM	IC50	J Med Chem (2023) 66: 11593-11631 [PMID:37647598]
ChEMBL	Inhibition of DPP4 (unknown origin)	B	7.3	pIC50	50	nM	IC50	J Med Chem (2014) 57: 2197-2212 [PMID:24099035]
ChEMBL	Inhibition of human recombinant DPP-4 using H-Gly-Pro-AMC as substrate after 10 mins by fluorescence assay	B	7.52	pIC50	30.3	nM	IC50	Bioorg Med Chem (2014) 22: 1383-1393 [PMID:24457090]
ChEMBL	Inhibition of DPP4	B	8.47	pIC50	3.4	nM	IC50	Bioorg Med Chem Lett (2010) 20: 3596-3600 [PMID:20483603]
ChEMBL	Inhibition of DPP4 in human plasma using Gly-Pro-AMC as substrate by fluorimetric analysis	B	8.47	pIC50	3.37	nM	IC50	Bioorg Med Chem (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL	Inhibition of human recombinant DPP4 by fluorescence assay	B	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4437-4440 [PMID:19482472]
ChEMBL	Inhibition of human DPP4 using Gly-Pro-AMC as substrate incubated for 30 mins by continuous fluorescent assay	B	8.82	pIC50	1.5	nM	IC50	Bioorg Med Chem Lett (2022) 76: 129018-129018 [PMID:36209967]
ChEMBL	Inhibition of human recombinant DPP-4 (1 to 530 residues) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by CF assay	B	8.82	pIC50	1.5	nM	IC50	J Med Chem (2023) 66: 11593-11631 [PMID:37647598]
ChEMBL	Inhibition of DPP4	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2011) 54: 5737-5746 [PMID:21711053]
dipeptidyl peptidase 4/Dipeptidyl peptidase 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3883] [GtoPdb: 1612] [UniProtKB: P28843]
ChEMBL	Inhibition of mouse DPP-4 using Gly-Pro-AMC as substrate measured after 5 mins by CF assay	B	8.72	pIC50	1.9	nM	IC50	J Med Chem (2023) 66: 11593-11631 [PMID:37647598]
dipeptidyl peptidase 8/Dipeptidyl peptidase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
ChEMBL	Binding affinity to DPP-8 (unknown origin) assessed as inhibition constant	B	6.29	pKi	508	nM	Ki	J Med Chem (2023) 66: 11593-11631 [PMID:37647598]
ChEMBL	Inhibition of DPP8	B	6.89	pKi	130	nM	Ki	J Med Chem (2006) 49: 6416-6420 [PMID:17034148]
ChEMBL	Inhibition of DPP8	B	6.61	pIC50	244	nM	IC50	Bioorg Med Chem (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL	Inhibition of DPP8	B	6.62	pIC50	240	nM	IC50	Bioorg Med Chem Lett (2010) 20: 3596-3600 [PMID:20483603]
dipeptidyl peptidase 9/Dipeptidyl peptidase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2]
ChEMBL	Binding affinity to DPP-9 (unknown origin) assessed as inhibition constant	B	7.01	pKi	98	nM	Ki	J Med Chem (2023) 66: 11593-11631 [PMID:37647598]
ChEMBL	Inhibition of DPP9	B	7.15	pKi	71	nM	Ki	J Med Chem (2006) 49: 6416-6420 [PMID:17034148]
ChEMBL	Inhibition of DPP9	B	6.98	pIC50	104	nM	IC50	Bioorg Med Chem (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL	Inhibition of DPP9	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (2010) 20: 3596-3600 [PMID:20483603]
prolyl endopeptidase/Prolyl endopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147]
ChEMBL	Inhibition of PEP (unknown origin)	B	5.11	pIC50	>7800	nM	IC50	J Med Chem (2023) 66: 11593-11631 [PMID:37647598]
fibroblast activation protein alpha/Prolyl endopeptidase FAP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884]
ChEMBL	Inhibition of FAPalpha (unknown origin)	B	5.89	pIC50	>1300	nM	IC50	J Med Chem (2023) 66: 11593-11631 [PMID:37647598]
ChEMBL	Inhibition of FAP (unknown origin)	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127253-127253 [PMID:32527554]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]