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ChEMBL ligand: CHEMBL1863513 (Ingenol Mebutate, Picato, AGN 204332, PEP-005, PEP005) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
GtoPdb | - | - | 9.42 | pKi | 0.38 | nM | Ki | Cancer Res. (2004) 64: 3243-55 [PMID:15126366] |
ChEMBL | Activation of PKCdelta (unknown origin) using phosphatidylserine as substrate | B | 8.39 | pEC50 | 4.1 | nM | EC50 | Bioorg. Med. Chem. Lett. (2013) 23: 5624-5629 [PMID:23993332] |
ChEMBL | Activation of PKCdelta (unknown origin) after 40 mins | B | 8.39 | pEC50 | 4.1 | nM | EC50 | Bioorg. Med. Chem. Lett. (2014) 24: 54-60 [PMID:24332494] |
protein kinase C alpha in Human [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
GtoPdb | - | - | 9.52 | pKi | 0.3 | nM | Ki | Cancer Res. (2004) 64: 3243-55 [PMID:15126366] |
protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
GtoPdb | - | - | 9.98 | pKi | 0.1 | nM | Ki | Cancer Res. (2004) 64: 3243-55 [PMID:15126366] |
protein kinase C gamma in Human [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
GtoPdb | - | - | 9.79 | pKi | 0.16 | nM | Ki | Cancer Res. (2004) 64: 3243-55 [PMID:15126366] |
protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
GtoPdb | - | - | 9.77 | pKi | 0.17 | nM | Ki | Cancer Res. (2004) 64: 3243-55 [PMID:15126366] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]