ChEMBL ligand: CHEMBL127 (ICI 194,660, ICI-194660, Meronem, Meropenem, Meropenem anhydrous, Meropenem, anhydrous, Meropenem (as trihydrate), Meropenem hydrate, Meropenem trihydrate, Merrem, Merrem i.v., Merrem iv, NSC-759621, SM-7338)
Beta-lactamase NDM-1 in Klebsiella pneumoniae [ChEMBL: CHEMBL1667695] [UniProtKB: C7C422] There should be some charts here, you may need to enable JavaScript!
Beta-lactamase VIM-2 in Pseudomonas aeruginosa [ChEMBL: CHEMBL5798] [UniProtKB: Q9K2N0] There should be some charts here, you may need to enable JavaScript!
OXA-48 in Klebsiella pneumoniae [ChEMBL: CHEMBL1287604] [UniProtKB: Q6XEC0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Beta-lactamase NDM-1 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667695] [UniProtKB: C7C422]
ChEMBL	Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay	B	4.96	pKd	11000	nM	Kd	Bioorg Med Chem Lett (2016) 26: 1973-1977 [PMID:26976213]
Beta-lactamase VIM-2 in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5798] [UniProtKB: Q9K2N0]
ChEMBL	Reversible binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 secs by SPR analysis	B	4.92	pKd	12000	nM	Kd	J Med Chem (2015) 58: 8671-8682 [PMID:26477515]
OXA-48 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287604] [UniProtKB: Q6XEC0]
ChEMBL	Binding affinity to native signal deficient and TEV cleavage site containing His-tagged Klebsiella pneumoniae OXA-48 expressed in Escherichia coli assessed as dissociation constant by SPR assay	B	6.07	pKd	850	nM	Kd	J Med Chem (2016) 59: 5542-5554 [PMID:27165692]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]