meropenem [Ligand Id: 10829] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL127 (Meropenem trihydrate, Meropenem hydrate, Merrem, Merrem iv, ICI 194,660, ICI-194660, SM-7338, Meropenem)
  • Beta-lactamase NDM-1 in Klebsiella pneumoniae [ChEMBL: CHEMBL1667695] [UniProtKB: C7C422]
  • This target only has 0 pki data point
  • 0
1 CHEMBL127_lig_chart_1 Beta-lactamase NDM-1 Klebsiella pneumoniae
There should be some charts here, you may need to enable JavaScript!
  • Beta-lactamase VIM-2 in Pseudomonas aeruginosa [ChEMBL: CHEMBL5798] [UniProtKB: Q9K2N0]
  • This target only has 0 pki data point
  • 0
2 CHEMBL127_lig_chart_2 Beta-lactamase VIM-2 Pseudomonas aeruginosa
There should be some charts here, you may need to enable JavaScript!
  • OXA-48 in Klebsiella pneumoniae [ChEMBL: CHEMBL1287604] [UniProtKB: Q6XEC0]
  • This target only has 0 pki data point
  • 0
3 CHEMBL127_lig_chart_3 OXA-48 Klebsiella pneumoniae
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactamase NDM-1 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667695] [UniProtKB: C7C422]
ChEMBL Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay B 4.96 pKd 11000 nM Kd Bioorg. Med. Chem. Lett. (2016) 26: 1973-1977 [PMID:26976213]
Beta-lactamase VIM-2 in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5798] [UniProtKB: Q9K2N0]
ChEMBL Reversible binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 secs by SPR analysis B 4.92 pKd 12000 nM Kd J. Med. Chem. (2015) 58: 8671-8682 [PMID:26477515]
OXA-48 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287604] [UniProtKB: Q6XEC0]
ChEMBL Binding affinity to native signal deficient and TEV cleavage site containing His-tagged Klebsiella pneumoniae OXA-48 expressed in Escherichia coli assessed as dissociation constant by SPR assay B 6.07 pKd 850 nM Kd J Med Chem (2016) 59: 5542-5554 [PMID:27165692]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]