ChEMBL ligand: CHEMBL127 (ICI 194,660, ICI-194660, Meronem, Meropenem, Meropenem anhydrous, Meropenem, anhydrous, Meropenem (as trihydrate), Meropenem hydrate, Meropenem trihydrate, Merrem, Merrem i.v., Merrem iv, NSC-759621, SM-7338)
Beta-lactamase NDM-1 in Klebsiella pneumoniae [ChEMBL: CHEMBL1667695] [UniProtKB: C7C422] There should be some charts here, you may need to enable JavaScript!
Beta-lactamase VIM-2 in Pseudomonas aeruginosa [ChEMBL: CHEMBL5798] [UniProtKB: Q9K2N0] There should be some charts here, you may need to enable JavaScript!
OXA-48 in Klebsiella pneumoniae [ChEMBL: CHEMBL1287604] [UniProtKB: Q6XEC0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Beta-lactamase NDM-1 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667695] [UniProtKB: C7C422]
ChEMBL	Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay	B	4.96	pKd	11000	nM	Kd	Bioorg Med Chem Lett (2016) 26: 1973-1977 [PMID:26976213]
Beta-lactamase VIM-2 in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5798] [UniProtKB: Q9K2N0]
ChEMBL	Reversible binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 secs by SPR analysis	B	4.92	pKd	12000	nM	Kd	J Med Chem (2015) 58: 8671-8682 [PMID:26477515]
OXA-48 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287604] [UniProtKB: Q6XEC0]
ChEMBL	Binding affinity to native signal deficient and TEV cleavage site containing His-tagged Klebsiella pneumoniae OXA-48 expressed in Escherichia coli assessed as dissociation constant by SPR assay	B	6.07	pKd	850	nM	Kd	J Med Chem (2016) 59: 5542-5554 [PMID:27165692]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]