L-152,804 [Ligand Id: 1565] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL491762 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929] | ||||||||
| ChEMBL | Inhibition of human neuropeptide Y1 receptor | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2008) 51: 4765-4770 [PMID:18637668] |
| Y2 receptor/Neuropeptide Y receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146] | ||||||||
| ChEMBL | Inhibition of human neuropeptide Y2 receptor | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2008) 51: 4765-4770 [PMID:18637668] |
| Y4 receptor/Neuropeptide Y receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391] | ||||||||
| ChEMBL | Inhibition of human neuropeptide Y4 receptor | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2008) 51: 4765-4770 [PMID:18637668] |
| Y5 receptor/Neuropeptide Y receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4561] [GtoPdb: 308] [UniProtKB: Q15761] | ||||||||
| ChEMBL | Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2009) 52: 3385-3396 [PMID:19459652] |
| ChEMBL | Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2008) 51: 4765-4770 [PMID:18637668] |
| GtoPdb | - | - | 7.6 | pKi | - | - | - | Biochem Biophys Res Commun (2000) 272: 169-73 [PMID:10872822] |
| ChEMBL | Antagonist activity at human recombinant neuropeptide Y5 receptor expressed in CHO cells coexpressing Gqi5 assessed as inhibition of neuropeptide Y-induced increase in intracellular calcium concentration | F | 7.21 | pIC50 | 61 | nM | IC50 | J Med Chem (2008) 51: 4765-4770 [PMID:18637668] |
| Y5 receptor in Rat [GtoPdb: 308] [UniProtKB: Q63634] | ||||||||
| GtoPdb | - | - | 7.5 | pKi | - | - | - | Biochem Biophys Res Commun (2000) 272: 169-73 [PMID:10872822] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
