Synonyms: example 93 [WO2019114770A1] | SIAIS 164029
Compound class:
Synthetic organic
Comment: SIAIS164029 is a PROTAC type degrader of ALK tyrosine kinase proteins [1]. The tyrosine kinase inhibitor moiety of the molecule is an alectinib analogue ('Id' in the patent), and the CRBN-binding ligand is pomalidomide.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
8-[4-[3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]propanoyl]piperazin-1-yl]-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile |
Synonyms ![]() |
example 93 [WO2019114770A1] | SIAIS 164029 |
Database Links ![]() |
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GtoPdb PubChem SID | 473153834 |
PubChem CID | 141762926 |
Search Google for chemical match using the InChIKey | NOXFUEOAHHPSKW-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | NOXFUEOAHHPSKW |
UniChem Compound Search for chemical match using the InChIKey | NOXFUEOAHHPSKW-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NOXFUEOAHHPSKW-UHFFFAOYSA-N |